6I0WA

Human carbonic anhydrase ii in complex with 4-methoxybenzenesulfonamide
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-254 231 1-23, 255-258 23 4 knot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 31x +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 23-254 232 1-22, 255-258 22 4 knot
Fingerprint Knot forming loop Loop type
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His96 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His96 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His96 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His96 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His96 <->
Bridging ionZn301
<-> His119 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His96 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His119 ... Val135 <->
Bridging ionHg302
<-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Asn62 <->
Bridging ionHg303
<-> His64 ... His94 <->
Bridging ionZn301
<-> His119 ... Gln137 <->
Bridging ionMbo304
<-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-256 231 1-25, 257-257 25 1 knot
view details
2.1 24-251 228 1-23 257-257 252-256 23 1 slipknot
sequence length 257
structure length 257
publication title Human Carbonic Anhydrase II in complex with 4-Methoxybenzenesulfonamide
rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 2
source organism Homo sapiens
total genus Genus: 75
ec nomenclature ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date 2018-10-26
KnotProt deposition date 2019-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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