6JOFA

Crystal structure of trmd from mycobacterium tuberculosis in complex with active-site inhibitor
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 81-130 50 1-80, 131-226 80 96 knot
Chain Sequence
MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDDAPYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTESHLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAG--------------------LEGPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQRTRERRPDL
sequence length 226
structure length 206
publication title Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
pubmed doi rcsb
molecule tags Transferase/inhibitor
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
source organism Mycobacterium tuberculosis h37rv
missing residues 159-178
total genus Genus: 60
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2019-03-20
KnotProt deposition date 2021-06-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
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