6NPLA

Cryo-em structure of nkcc1
Slipknot S 41 +31 +31 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 33-226 194 227-931 1-17 18-32 17 704 slipknot
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41 14-261 248 1-13 325-931 262-324 13 607 slipknot
Chain Sequence
KFGWIKGVLVRCMLNIWGVMLFIRMTWIVGQAGIAYSCIIVIMATVVTTITGCSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVELLMDSGLLMIDQTNDIRVIGTITVILLLGISVAGMEWEAKAQIFLLVILITAIFNYFIGSFIAVDSKKKFGFFSYDAGILAENFGPDFRGQTFFSVFSIFFPAATGILAGANISGDLADPQMAIPKGTLLAILITGLVYVGVAISAGACIVRDATGIESNFTLISNCTDAACKYGYDFSSCRPTVEGEVSSCKFGLHNDFQVMSVVSGFSPLISAGIFSATLSSALASLVSAPKVFQALCKDNIYPGIAIFGKGYGKNNEPLRGYFLTFGIALAFILIAELNVIAPIISNFFLASYALINFSVFHASLANSPGWRPSFKYYNMWASLAGAILCCVVMFIINWWAALLTNVIVLSLYIYVSYKKPDVNWGSSTQALTYHQALTHSLQLCGVADHIKTFRPQCLVMTGAPNSRPAILHLVHAFTKNVGLMLCGHVRISSRRPNFKELNSDMLRYQRWLLNNNSKAFYTCVVAEDLRQGTQYMLQAAGLGRLRPNTLVIGFKNDWRIGDIKEVETYINLIHDAFDFQYGVVILRLREGLDISH-----------------------------------------------------LNVADQRLLDSQQFQQKQGKGTVDVWWLFDDGGLTLLIPYLIANKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDITVLGDINTKPKSEGLTEFAEMIEPYKLREDDMEQEAAEKLKSEEPWRITDNELELYKAKGNRQIRLNELLKEHSSTANLIVMSMPLARKGAVSSALYMAWLDTLSKDLPPILLVRGNHQSVLTFYS
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 7-254 248 1-6 264-914 255-263 6 651 slipknot
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3.2 8-267 260 1-6, 277-914 7-7, 268-276 6 638 slipknot
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3.2 12-308 297 1-11 331-914 309-330 11 584 slipknot
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3.2 16-266 251 1-9, 277-914 10-15, 267-276 9 638 slipknot
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3.2 16-276 261 1-9, 279-914 10-15, 277-278 9 636 slipknot
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1.1 35-241 207 1-13, 259-914 14-34, 242-258 13 656 slipknot
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2.1 35-214 180 1-14, 242-914 15-34, 215-241 14 673 slipknot
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2.1 34-336 303 1-14, 389-914 15-33, 337-388 14 526 slipknot
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1.1 30-211 182 1-19, 215-914 20-29, 212-214 19 700 slipknot
sequence length 914
structure length 861
publication title Structure and mechanism of the cation-chloride cotransporter NKCC1.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Solute carrier family 12 (sodium/potassium/chloride transporter), member 2
source organism Danio rerio
missing residues 651-703
total genus Genus: 214
ec nomenclature
pdb deposition date 2019-01-17
KnotProt deposition date 2019-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03522 SLC12 Solute carrier family 12
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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