6QNL | KnotProt

Genus: 69
Alphaknot: O43570

Knot K +3₁

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	23-255	233	1-22, 256-258			22	3	knot

Chain Sequence

KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTS

Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!

Knot K 3x +3₁

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Help Knotting data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Type
view details	+ 3₁	23-255	233	1-22, 256-258	22	3	knot
view details	+ 3₁	24-233	210	1-23, 234-237	23	4	knot
view details	+ 3₁	23-231	209	1-22, 232-235	22	4	knot

	Fingerprint	Knot forming loop	Loop type
knots details	K +3₁	Lys4 ... His94 <-> Bridging ionZn301 <-> His96 ... Ser261 <-> Lys4	probabilistic	color sequence
knots details	K +3₁	Lys4 ... His96 <-> Bridging ionZn301 <-> His119 ... Ser261 <-> Lys4	probabilistic	color sequence
knots details	K +3₁	Lys4 ... His94 <-> Bridging ionZn301 <-> His119 ... Ser261 <-> Lys4	probabilistic	color sequence

Chain Sequence

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

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Help Knotoid subchains data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				3.1	25-257	233	1-24, 258-260			24	3	knot
view details				2.1	24-254	231	1-23	260-260	255-259	23	1	slipknot

sequence length	260
structure length	260
publication title	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide rcsb
molecule tags	Lyase
molecule keywords	Carbonic anhydrase 12
source organism	Homo sapiens
total genus	Genus: 69
ec nomenclature	ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date	2019-02-11
KnotProt deposition date	2020-03-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00194	Carb_anhydrase	Eukaryotic-type carbonic anhydrase

Image from the rcsb pdb (www.rcsb.org)

1JD0A 4HT2A 6QN0A 6QNGA 6QNLA
similar chains in the KnotProt database (40% sequence similarity)

7PP9A 8CO3A 9R0LA 9R0UA
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1JD0 A; 4HT2 A; 6QN0 A; 6QNG A; 6QNL A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)
7PP9 A; 8CO3 A; 9R0L A; 9R0U A;

6QNLA

Knot K +31

Chain Sequence

Knot K 3x +31

Chain Sequence

pfam database annotations

Knot K +3₁

Knot K 3x +3₁