6QNLA

Three dimensional structure of human carbonic anhydrase xii in complex with benzenesulfonamide
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 23-255 233 1-22, 256-258 22 3 knot
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 23-255 233 1-22, 256-258 22 3 knot
Fingerprint Knot forming loop Loop type
K +31 Lys4 ... His94 <->
Bridging ionZn301
<-> His96 ... Ser261 <-> Lys4
probabilistic
K +31 Lys4 ... His96 <->
Bridging ionZn301
<-> His119 ... Ser261 <-> Lys4
probabilistic
K +31 Lys4 ... His94 <->
Bridging ionZn301
<-> His119 ... Ser261 <-> Lys4
probabilistic
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 25-257 233 1-24, 258-260 24 3 knot
view details
2.1 24-254 231 1-23 260-260 255-259 23 1 slipknot
sequence length 260
structure length 260
publication title Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide
rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 12
source organism Homo sapiens
ec nomenclature ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date 2019-02-11
KnotProt deposition date 2020-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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