6QQMA

Crystal structure of the alpha carbonic anhydrase from schistosoma mansoni
Genus: 84
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 28-272 245 1-27, 273-277 27 5 knot
Chain Sequence
EWSYTNILTGPETWHEHYKNMCSGYYQSPIDLKTDISTLDLKLKTVIIYRNTSSTETTTIQNNGHSAEVKFPRNTWFISFDGILDYKYEIIQMHFHWGNTDDRGSEHTIDGFRFPLEGHIVSFRRQMYSSPSEAIGRPGGLAVLGIMHQIVESIKYEQTAFKAYNNFSGVLNSQFVPPNNSTIDDINLALLLSLLNPSRYFRYLGSLTTPPCTENVLWTVFIDPVLITREQINLFRNLPYGSNEKQTRMGDNFRPIQLLNPIDTLASRTLYRATARG
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 26-248 223 1-25, 249-254 25 6 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureGlu24 <-> Gly300
... His142 <->
Bridging ionZn401
<-> His117 ... Glu24		 probabilistic
K +31
Chain closureGlu24 <-> Gly300
... His119 <->
Bridging ionZn401
<-> His117 ... Glu24		 probabilistic
K +31
Chain closureGlu24 <-> Gly300
... His142 <->
Bridging ionZn401
<-> His119 ... Glu24		 probabilistic
Chain Sequence
EWSYTNILTGPETWHEHYKNMCSGYYQSPIDLKTDISTLDLKLKTVIIYRNTSSTETTTIQNNGHSAEVKFPRNTWFISFDGILDYKYEIIQMHFHWGNTDDRGSEHTIDGFRFPLEGHIVSFRRQMYSSPSEAIGRPGGLAVLGIMHQIVESIKYEQTAFKAYNNFSGVLNSQFVPPNNSTIDDINLALLLSLLNPSRYFRYLGSLTTPPCTENVLWTVFIDPVLITREQINLFRNLPYGSNEKQTRMGDNFRPIQLLNPIDTLASRTLYRATARG
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 28-272 245 1-27, 273-277 27 5 knot
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2.1 25-269 245 1-24 274-277 270-273 24 4 slipknot
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2.1 31-274 244 275-277 1-27 28-30 27 2 slipknot
sequence length 277
structure length 277
publication title Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Putative carbonic anhydrase
source organism Schistosoma mansoni
total genus Genus: 84
ec nomenclature ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date 2019-02-18
KnotProt deposition date 2019-11-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling