6QRBA

Crystal structure of trmd, a trna-(n1g37) methyltransferase, from mycobacterium abscessus in complex with inhibitor
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 84-132 49 1-83, 133-229 83 97 knot
Chain Sequence
GSMKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSVDDSPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRLVPGVLGNALSAQ---------SLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIERRPDLL
sequence length 229
structure length 220
publication title Development of Inhibitors against Mycobacterium abscessus tRNA (m 1 G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
pubmed doi rcsb
molecule tags Transferase
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
source organism Mycobacterium abscessus
missing residues 170-178
total genus Genus: 55
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2019-02-19
KnotProt deposition date 2021-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
6NW7A
similar chains in the KnotProt database (40% sequence similarity)
6NVRA 6NW6A 6QO2A 6QO3A 6QO4A 6QO6A 6QOAA 6QOCA
similar chains in the pdb database (40% sequence similarity)

 
#similar chains in the KnotProt database (40% sequence similarity)
6NW7 A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)
6NVR A; 6NW6 A; 6QO2 A; 6QO3 A; 6QO4 A; 6QO6 A; 6QOA A; 6QOC A; 

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