6QRFA

Crystal structure of trmd, a trna-(n1g37) methyltransferase, from mycobacterium abscessus in complex with inhibitor
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 83-131 49 1-82, 132-228 82 97 knot
Chain Sequence
SMKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSVDDSPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRLVPGVLG---------------SLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIERRPDLL
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 82-133 52 1-81, 134-228 81 95 knot
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2.1 85-158 74 159-228 1-81 82-84 81 69 slipknot
missing residues 163-177
publication title Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
pubmed doi rcsb
structure length 213
molecule tags Transferase
source organism Mycobacterium abscessus
sequence length 228
total genus Genus: 56
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
ec nomenclature ec 2.1.1.228: Alcohol dehydrogenase.
pdb deposition date 2019-02-19
KnotProt deposition date 2019-10-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
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