6RRGA

Human carbonic anhydrase ii in complex with fluorinated benzenesulfonamide
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-255 232 1-23, 256-258 23 3 knot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 15x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 29-187 159 1-28, 188-190 28 3 knot
Fingerprint Knot forming loop Loop type
K +31 His4 ... Gln137 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Val135 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His96 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... Gln137 <-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His96 ... Gln137 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His96 ... Val135 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His96 ... Gln137 <-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His119 ... Gln137 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His119 ... Val135 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <-> His119 ... Gln137 <-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <-> His119 ... Gln137 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <-> His119 ... Val135 <-> Cys206 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His96 <-> His119 ... Gln137 <-> Glu205 ...
Chain closureLys261 <-> His4
probabilistic
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
sequence length 257
structure length 257
publication title The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 2
source organism Homo sapiens
total genus Genus: 74
ec nomenclature ec 4.2.1.1: Carbonic anhydrase.
pdb deposition date 2019-05-17
KnotProt deposition date 2021-05-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
3M2YA 5M78A 6GDCA 5LL8A 6HQXA
similar chains in the KnotProt database (40% sequence similarity)
3M14A 3M1KA 3M2XA 6GM9A
similar chains in the pdb database (40% sequence similarity)

 
#similar chains in the KnotProt database (40% sequence similarity)
3M2Y A; 5M78 A; 6GDC A; 
#similar chains, but unknotted
6HQX A; 
#similar chains in the pdb database (40% sequence similarity)
3M14 A; 3M1K A; 3M2X A; 6GM9 A; 

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