6RVXA

Inward-open structure of the asct2 (slc1a5) mutant c467r in presence of tboa
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 100
Slipknot S +31 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-367 322 1-45 378-447 368-377 45 70 slipknot
Chain Sequence
DQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAAS-----------------SKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSRTVLNVEGDALGAGLLQNYVDRT
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 58-359 302 1-57 383-447 360-382 57 65 slipknot
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2.1 14-400 387 1-13 407-447 401-406 13 41 slipknot
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2.1 48-353 306 1-30, 359-447 31-47, 354-358 30 89 slipknot
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1.1 69-363 295 1-57, 379-447 58-68, 364-378 57 69 slipknot
sequence length 447
structure length 430
publication title A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Neutral amino acid transporter B(0)
source organism Homo sapiens
missing residues 118-134
total genus Genus: 100
ec nomenclature
pdb deposition date 2019-06-03
KnotProt deposition date 2019-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00375 SDF Sodium:dicarboxylate symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling