6RVYA

Inward-open structure of the asct2 (slc1a5) mutant c467r in absence of substrate
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 120
Slipknot S +31 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 47-365 319 1-46 377-447 366-376 46 71 slipknot
Chain Sequence
DQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAAS-----------------SKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSRTVLNVEGDALGAGLLQNYVDRT
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 59-355 297 1-58 382-447 356-381 58 66 slipknot
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2.1 12-400 389 1-11 407-447 401-406 11 41 slipknot
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2.1 68-364 297 1-58, 379-447 59-67, 365-378 58 69 slipknot
sequence length 447
structure length 430
publication title A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Neutral amino acid transporter B(0)
source organism Homo sapiens
missing residues 118-134
total genus Genus: 120
ec nomenclature
pdb deposition date 2019-06-03
KnotProt deposition date 2019-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00375 SDF Sodium:dicarboxylate symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling