6VWUA

X-ray structure of alks 4230, a fusion of circularly permuted human interleukin-2 and interleukin-2 receptor alpha
Cysteine knot
Loop Piercing
view details
168-c-184-b-242-c-199 166-b-197
Chain Sequence
NFHLRPRDLISNINVIVLELKGT---FMCEYADETATIVEFLNRWITFSQSIISTLTGGSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQGSGSEL--CDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSHCREPP--------------------------------------PWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTG
sequence length 301
structure length 258
publication title ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy.
pubmed doi rcsb
molecule tags Cytokine
molecule keywords Interleukin-2,Interleukin-2 receptor subunit alpha
source organism Homo sapiens
missing residues 23-25, 133-134, 201-238
ec nomenclature
pdb deposition date 2020-02-20
Image from the rcsb pdb (www.rcsb.org)
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