4ZG6A

Structural basis for inhibition of human autotaxin by four novel compounds
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 511-302 -208 1-510 643-804 303-642 510 162 slipknot
Chain Sequence
GSCKGRCFEL-------CRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIAALTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPFFQGDHG-----------FDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGTEERHLLYGRPAVLYRTR-------------------------YDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAK-------YDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYE
sequence length 804
structure length 754
publication title Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
source organism Homo sapiens
missing residues 11-17, 403-413, 511-535, 588-594
ec nomenclature
pdb deposition date 2015-04-22
KnotProt deposition date 2015-10-14
Image from the rcsb pdb (www.rcsb.org)
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 107-296 190 1-106 411-754 297-410 106 344 slipknot
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3.1 103-410 308 1-1, 413-754 2-102, 411-412 1 342 slipknot
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2.1m 493-574 82 1-492 585-754 575-584 492 170 slipknot
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3.1m 37-584 548 1-36 590-754 585-589 36 165 slipknot
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2.1m 492-584 93 1-491 595-754 585-594 491 160 slipknot
5OHIA 4ZG7A 3NKQA 3NKRA 3WAYA 3NKOA 3NKPA 5OLBA 3NKNA 3WAVA 5DLWA 3WAXA 3NKMA 4ZG6A 5IJQA 3WAWA 2XR9A 5DLVA 5IJSA 5M0SA 4GTWA 4B56A 2XRGA 4GTXA 4GTZA 4GTYA
similar chains in the KnotProt database (40% sequence similarity)
5DLTA 5INHA 5LIAA 6C02A 6C02B 5HRTA 4ZG6B 5M0EA 5DLVB 5GZ5A 5M0MA 6C01A 6C01B 5L0BA 5L0BB 5KXAA 5MHPA 5LQQA 5M0DA 4ZGAA 4ZG9A 4ZG9B 5GZ4A 5L0EA 5L0EB 5L0KA 5L0KB 5M7MA 4GTWB 4B56B 4GTXB 4GTZB 4GTYB
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 5OHI A;  4ZG7 A;  3NKQ A;  3NKR A;  3WAY A;  3NKO A;  3NKP A;  5OLB A;  3NKN A;  3WAV A;  5DLW A;  3WAX A;  3NKM A;  4ZG6 A;  5IJQ A;  3WAW A;  2XR9 A;  5DLV A;  5IJS A;  5M0S A;  4GTW A;  4B56 A;  2XRG A;  4GTX A;  4GTZ A;  4GTY A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5DLT A;  5INH A;  5LIA A;  6C02 A;  6C02 B;  5HRT A;  4ZG6 B;  5M0E A;  5DLV B;  5GZ5 A;  5M0M A;  6C01 A;  6C01 B;  5L0B A;  5L0B B;  5KXA A;  5MHP A;  5LQQ A;  5M0D A;  4ZGA A;  4ZG9 A;  4ZG9 B;  5GZ4 A;  5L0E A;  5L0E B;  5L0K A;  5L0K B;  5M7M A;  4GTW B;  4B56 B;  4GTX B;  4GTZ B;  4GTY B; 
           

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