5KHUT

Model of human anaphase-promoting complex/cyclosome (apc15 deletion mutant), in complex with the mitotic checkpoint complex (apc/c-cdc20-mcc) based on cryo em data at 4.8 angstrom resolution
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core rangeKnot core lengthKnot tails rangeSlipknot tails rangeSlipknot loops rangeN-end lengthC-end lengthType
view details
+31 86-176 91 1-77, 181-194 78-85, 177-180 77 14 slipknot
Chain Sequence
TLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECD-----------KSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
sequence length 194
structure length 183
publication title Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
pubmed doi rcsb
molecule tags Cell cycle
molecule keywords Anaphase-promoting complex subunit 1
source organism Homo sapiens
missing residues 97-107
ec nomenclature
pdb deposition date2016-06-15
KnotProt deposition date2016-09-09
Image from the rcsb pdb (www.rcsb.org)
4AEZB 2V64A 5KHUT 2VFXA 1GO4A 2QYFA 2V64D 3GMHA 5LCWZ 1S2HA 1KLQA 1DUJA
similar chains in the KnotProt database (40% sequence similarity)
2VFXB 2VFXC 2VFXD 2VFXE 2VFXF 2VFXG 2VFXH 2VFXI 2VFXJ 2VFXK 2VFXL 1GO4B 1GO4C 1GO4D 2QYFC 4AEZE 4AEZH 2V64C 2V64F 2V64E 2V64H 3GMHB 3GMHC 3GMHD 3GMHE 3GMHF 3GMHG 3GMHH 3GMHI 3GMHJ 3GMHK 3GMHL
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 4AEZ B;  2V64 A;  5KHU T; 
               
               
#similar chains, but unknotted
 2VFX A;  1GO4 A;  2QYF A;  2V64 D;  3GMH A;  5LCW Z;  1S2H A;  1KLQ A;  1DUJ A;                               
               
           
#similar chains in the pdb database (40% sequence similarity)
 2VFX B;  2VFX C;  2VFX D;  2VFX E;  2VFX F;  2VFX G;  2VFX H;  2VFX I;  2VFX J;  2VFX K;  2VFX L;  1GO4 B;  1GO4 C;  1GO4 D;  2QYF C;  4AEZ E;  4AEZ H;  2V64 C;  2V64 F;  2V64 E;  2V64 H;  3GMH B;  3GMH C;  3GMH D;  3GMH E;  3GMH F;  3GMH G;  3GMH H;  3GMH I;  3GMH J;  3GMH K;  3GMH L; 
           

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