5KHUT

Model of human anaphase-promoting complex/cyclosome (apc15 deletion mutant), in complex with the mitotic checkpoint complex (apc/c-cdc20-mcc) based on cryo em data at 4.8 angstrom resolution
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 86-176 91 1-77, 181-194 78-85, 177-180 77 14 slipknot
Chain Sequence
TLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECD-----------KSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 88-160 73 1-76, 176-183 77-87, 161-175 76 8 slipknot
missing residues 97-107
publication title Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
pubmed doi rcsb
structure length 183
molecule tags Cell cycle
source organism Homo sapiens
sequence length 194
molecule keywords Anaphase-promoting complex subunit 1
ec nomenclature
pdb deposition date 2016-06-15
KnotProt deposition date 2016-09-09
Image from the rcsb pdb (www.rcsb.org)
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