5TCDA

Human alkaline sphingomyelinase (enpp7) in complex with phosphocholine
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 9-217 209 1-8 336-388 218-335 8 53 slipknot
Chain Sequence
QNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTES
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 6-217 212 1-5 224-388 218-223 5 165 slipknot
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2.1 8-219 212 1-7 328-388 220-327 7 61 slipknot
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3.1 6-328 323 1-5 334-388 329-333 5 55 slipknot
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2.1 9-283 275 1-7, 293-388 8-8, 284-292 7 96 slipknot
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2.1 10-263 254 1-7, 272-388 8-9, 264-271 7 117 slipknot
publication title Crystal Structure of the Human Alkaline Sphingomyelinase Provides Insights into Substrate Recognition.
pubmed doi rcsb
structure length 388
molecule tags Hydrolase
source organism Homo sapiens
sequence length 388
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
ec nomenclature
pdb deposition date 2016-09-14
KnotProt deposition date 2017-03-26
Image from the rcsb pdb (www.rcsb.org)
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