5TPQA

E. coli alkaline phosphatase d101a, d153a, r166s, e322a, k328a mutant
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-361 321 1-40 412-446 362-411 40 35 slipknot
Chain Sequence
ENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTASAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQAATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVAGASIDAQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLKWSHP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 40-364 325 1-39 406-446 365-405 39 41 slipknot
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3.1 39-405 367 1-38 407-446 406-406 38 40 slipknot
view details
3.1 38-406 369 1-37 412-446 407-411 37 35 slipknot
view details
2.1 36-359 324 1-13, 365-446 14-35, 360-364 13 82 slipknot
publication title Differential Catalytic Promiscuity of the Alkaline Phosphatase Superfamily Bimetallo Core Reveals Mechanistic Features Underlying Enzyme Evolution
doi rcsb
structure length 446
molecule tags Hydrolase
source organism Escherichia coli (strain k12)
sequence length 446
molecule keywords Alkaline phosphatase
ec nomenclature
pdb deposition date 2016-10-20
KnotProt deposition date 2017-11-01
Image from the rcsb pdb (www.rcsb.org)
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