5TT3A

Crystal structure of the complex of helicobacter pylori alpha-carbonic anhydrase with ethoxzolamide
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 28-219 192 1-27, 220-226 27 7 knot
Chain Sequence
KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQ---NFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 29-204 176 1-28, 205-211 28 7 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureLys22 <-> Arg247
... His129 <->
Bridging ionZn301
<-> His112 ... Lys22
probabilistic
K +31
Chain closureLys22 <-> Arg247
... His129 <->
Bridging ionZn301
<-> His110 ... Lys22
probabilistic
K +31
Chain closureLys22 <-> Arg247
... His112 <->
Bridging ionZn301
<-> His110 ... Lys22
probabilistic
Chain Sequence
KWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQ---NFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 30-222 193 1-29, 223-226 29 4 knot
view details
2.1 29-217 189 1-28 224-226 218-223 28 3 slipknot
missing residues 143-145
publication title Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
pubmed doi rcsb
structure length 223
molecule tags Lyase
source organism Helicobacter pylori (strain atcc 700392 / 26695)
sequence length 226
molecule keywords Alpha-carbonic anhydrase
ec nomenclature
pdb deposition date 2016-11-01
KnotProt deposition date 2018-10-04
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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