6KKUA

Human kcc1 structure determined in nacl and gdn
Slipknot S 41 +31 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 30-328 299 329-537 1-19 20-29 19 208 slipknot
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41 11-363 353 1-10 402-537 364-401 10 136 slipknot
Chain Sequence
PSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 6-357 352 1-5 365-537 358-364 5 173 slipknot
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3.2 9-376 368 1-8 386-537 377-385 8 152 slipknot
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3.2 10-387 378 1-9 404-537 388-403 9 134 slipknot
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2.1 34-408 375 1-15, 455-537 16-33, 409-454 15 83 slipknot
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2.1 35-316 282 1-16, 347-537 17-34, 317-346 16 191 slipknot
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2.1 34-346 313 1-17, 357-537 18-33, 347-356 17 181 slipknot
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2.1 35-477 443 478-537 1-16 17-34 16 59 slipknot
sequence length 537
structure length 537
publication title Cryo-EM structures of the human cation-chloride cotransporter KCC1.
doi rcsb
molecule tags Transport protein
molecule keywords Solute carrier family 12 member 4
source organism Homo sapiens
ec nomenclature
pdb deposition date 2019-07-27
KnotProt deposition date 2019-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00324 AA_permease Amino acid permease
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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