6QOEA

Crystal structure of trmd, a trna-(n1g37) methyltransferase, from mycobacterium abscessus in complex with fragment 8 (3-[(2-thienylthio)methyl]benzoic acid)
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 84-132 49 1-83, 133-229 83 97 knot
Chain Sequence
GSMKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSVDDSPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRLVPGVL----------------SLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIERRPDLL
sequence length 229
structure length 213
publication title Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
pubmed doi rcsb
molecule tags Transferase
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
source organism Mycobacterium abscessus
missing residues 163-178
total genus Genus: 49
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2019-02-12
KnotProt deposition date 2021-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
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