5YR7A

Human methionine aminopeptidase type 1b (f309l mutant)
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 4x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 116-213 98 1-115, 214-242 115 29 knot
Fingerprint Knot forming loop Loop type
K +31 Tyr90 ... His303 <->
Bridging ionCo402
<-> Glu336 ...
Chain closureSer393 <-> Tyr90
probabilistic
K +31 Val209 <->
Bridging ionNa405
<-> Ser363 ... Val209
ion-based
K +31 Asn207 ... Glu336 <->
Bridging ionCo402
<-> Glu367 ... Ser363 <->
Bridging ionNa405
<-> Asn207
ion-based
K +31 Asn207 <->
Bridging ionNa405
<-> Ser363 ... Glu336 <->
Bridging ionCo402
<-> Asp240 ... Asn207
ion-based
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLLHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
sequence length 304
structure length 304
publication title Differential inhibition of Sub-Type 1 Methionine aminopeptidases by ovalicin
rcsb
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
source organism Homo sapiens
total genus Genus: 102
ec nomenclature
pdb deposition date 2017-11-08
KnotProt deposition date 2018-11-21
Image from the rcsb pdb (www.rcsb.org)
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