6QUTA

Three dimensional structure of human carbonic anhydrase ix in complex with benzenesulfonamide
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 23-249 227 250-253 1-3 4-22 3 3 slipknot
Chain Sequence
WRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 19-251 233 252-253 1-1 2-18 1 1 slipknot
Fingerprint Knot forming loop Loop type
K +31 Trp5 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closurePro257 <-> Trp5
probabilistic
K +31 Trp5 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closurePro257 <-> Trp5
probabilistic
K +31 Trp5 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closurePro257 <-> Trp5
probabilistic
Chain Sequence
WRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 12-245 234 1-11 251-251 246-250 11 1 slipknot
sequence length 251
structure length 251
publication title Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide
rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 9
source organism Homo sapiens
total genus Genus: 68
ec nomenclature ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date 2019-02-28
KnotProt deposition date 2020-04-07
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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