6R71 | KnotProt

Genus: 79
Alphaknot: O43570

Slipknot S +3₁

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	24-256	233	1-23, 257-261			23	4	slipknot

Chain Sequence

KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ

Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!

Knot K 3x +3₁

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Help Knotting data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Type
view details	+ 3₁	25-256	232	1-24, 257-261	24	4	slipknot
view details	+ 3₁	24-232	209	1-23, 233-237	23	5	knot
view details	+ 3₁	23-234	212	1-22, 235-239	22	5	knot

	Fingerprint	Knot forming loop	Loop type
knots details	K +3₁	Lys3 ... His91 <-> Bridging ionZn301 <-> His93 ... Chain closureGln263 <-> Lys3	probabilistic	color sequence
knots details	K +3₁	Lys3 ... His91 <-> Bridging ionZn301 <-> His117 ... Chain closureGln263 <-> Lys3	probabilistic	color sequence
knots details	K +3₁	Lys3 ... His93 <-> Bridging ionZn301 <-> His117 ... Chain closureGln263 <-> Lys3	probabilistic	color sequence

Chain Sequence

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

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Help Knotoid subchains data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				2.1	25-258	234	1-24, 259-261			24	3	knot
view details				2.1	24-254	231	1-23	260-261	255-259	23	2	slipknot

sequence length	261
structure length	261
publication title	Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. pubmed doi rcsb
molecule tags	Lyase
molecule keywords	Carbonic anhydrase 12
source organism	Homo sapiens
total genus	Genus: 79
ec nomenclature	ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date	2019-03-28
KnotProt deposition date	2020-04-17

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00194	Carb_anhydrase	Eukaryotic-type carbonic anhydrase

Image from the rcsb pdb (www.rcsb.org)

4KP5A 4KP8A 4Q0LA 4QJ0A 4QJOA 4QJWA 5LL5A 5LL9A 4WW8A
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
4KP5 A; 4KP8 A; 4Q0L A; 4QJ0 A; 4QJO A; 4QJW A; 5LL5 A; 5LL9 A; 
#similar chains, but unknotted
4WW8 A; 
#similar chains in the pdb database (40% sequence similarity)

6R71A

Slipknot S +31

Chain Sequence

Knot K 3x +31

Chain Sequence

pfam database annotations

Slipknot S +3₁

Knot K 3x +3₁