6Y74A

X-ray crystal structure of human carbonic anhydrase ix catalytic domain.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-251 228 1-23, 252-258 23 7 knot
Chain Sequence
DQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGV
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 23-251 229 1-22, 252-258 22 7 knot
Fingerprint Knot forming loop Loop type
K +31 Asp137 ... His226 <->
Bridging ionZn504
<-> His228 ...
Chain closureVal394 <-> Asp137
probabilistic
K +31 Asp137 ... His228 <->
Bridging ionZn504
<-> His251 ...
Chain closureVal394 <-> Asp137
probabilistic
K +31 Asp137 ... His226 <->
Bridging ionZn504
<-> His251 ...
Chain closureVal394 <-> Asp137
probabilistic
Chain Sequence
DQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGV
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-253 228 1-25, 254-258 25 5 knot
view details
1.1 29-250 222 1-23, 254-258 24-28, 251-253 23 5 slipknot
sequence length 258
structure length 258
publication title Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 9
source organism Homo sapiens
total genus Genus: 68
ec nomenclature ec 4.2.1.1: Alcohol dehydrogenase.
pdb deposition date 2020-02-28
KnotProt deposition date 2020-08-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling