1OQHA

Crystal structure of the r124a mutant of the n-lobe human transferrin
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 2x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 20-161 142 1-19, 162-220 19 58 slipknot
Fingerprint Knot forming loop Loop type
K +31 Asp63 <->
Bridging ionFe500
<-> Tyr188 ... Cys331 <-> Cys137 ... Asp63		 ion-based
K +31 Asp63 <->
Bridging ionFe500
<-> Tyr188 ... Cys227 <-> Cys241 ... Cys331 <-> Cys137 ... Asp63		 ion-based
Chain Sequence
DKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGASAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
sequence length 329
structure length 329
publication title Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Serotransferrin
source organism Homo sapiens
total genus Genus: 106
ec nomenclature
pdb deposition date 2003-03-10
KnotProt deposition date 2018-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00405 Transferrin Transferrin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1oqhA01
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1oqhA02
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1oqhA01
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1oqhA02
1A8FA 2O7UA 1N84A 1N7XA 1A8EA 1FQFA 1OQHA 3FGSA 1FQEA 1D3KA 1N7WA 1DTGA 3O97A 1B3EA 1JQFA 1D4NA 2O84X 1OQGA
chains in the KnotProt database with same CATH superfamily
1A8FA 2O7UA 1N84A 1N7XA 1A8EA 1FQFA 1OQHA 3FGSA 1FQEA 1D3KA 1N7WA 1DTGA 3O97A 1B3EA 1JQFA 1D4NA 2O84X 1OQGA
chains in the KnotProt database with same CATH topology
1A8FA 2O7UA 1N84A 1N7XA 1A8EA 1FQFA 1OQHA 3FGSA 1FQEA 1D3KA 1N7WA 1DTGA 3O97A 1B3EA 1JQFA 1D4NA 2O84X 1OQGA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1A8F A;  2O7U A;  1N84 A;  1N7X A;  1A8E A;  1FQF A;  1OQH A;  3FGS A;  1FQE A;  1D3K A;  1N7W A;  1DTG A;  3O97 A;  1B3E A;  1JQF A;  1D4N A;  2O84 X;  1OQG A; 
#chains in the KnotProt database with same CATH topology
 1A8F A;  2O7U A;  1N84 A;  1N7X A;  1A8E A;  1FQF A;  1OQH A;  3FGS A;  1FQE A;  1D3K A;  1N7W A;  1DTG A;  3O97 A;  1B3E A;  1JQF A;  1D4N A;  2O84 X;  1OQG A; 
#chains in the KnotProt database with same CATH homology
 1A8F A;  2O7U A;  1N84 A;  1N7X A;  1A8E A;  1FQF A;  1OQH A;  3FGS A;  1FQE A;  1D3K A;  1N7W A;  1DTG A;  3O97 A;  1B3E A;  1JQF A;  1D4N A;  2O84 X;  1OQG A;
1OQGA 3S9LC 3S9MC 1BP5A 1BTJA
similar chains in the KnotProt database (40% sequence similarity)
3QYTA 3S9NC 3V83A 3V8XB
similar chains in the pdb database (40% sequence similarity)

  
#similar chains in the KnotProt database (40% sequence similarity)
1OQG A; 3S9L C; 3S9M C; 
#similar chains, but unknotted
1BTJ A; 
#similar chains in the pdb database (40% sequence similarity)
3QYT A; 3S9N C; 3V83 A; 3V8X B;
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling
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