1N7WA

Crystal structure of human serum transferrin, n-lobe l66w mutant
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 2x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 20-160 141 1-19, 161-220 19 59 slipknot
Fingerprint Knot forming loop Loop type
K +31 Asp63 <->
Bridging ionFe339
<-> Tyr188 ... Cys331 <-> Cys137 ... Asp63
ion-based
K +31 Asp63 <->
Bridging ionFe339
<-> Tyr188 ... Cys227 <-> Cys241 ... Cys331 <-> Cys137 ... Asp63
ion-based
Chain Sequence
DKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGWVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
sequence length 329
structure length 329
publication title The Position of Arginine 124 Controls the Rate of Iron Release from the N-lobe of Human Serum Transferrin. A Structural Study
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Serotransferrin
source organism Homo sapiens
total genus Genus: 105
ec nomenclature
pdb deposition date 2002-11-18
KnotProt deposition date 2018-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00405 Transferrin Transferrin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1n7wA01
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1n7wA02
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1n7wA01
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 1n7wA02
1DTGA 3FGSA 1N84A 1FQEA 3O97A 2O7UA 1A8FA 1D3KA 1OQGA 1FQFA 1N7WA 2O84X 1D4NA 1OQHA 1A8EA 1JQFA 1B3EA 1N7XA
chains in the KnotProt database with same CATH superfamily
1DTGA 3FGSA 1N84A 1FQEA 3O97A 2O7UA 1A8FA 1D3KA 1OQGA 1FQFA 1N7WA 2O84X 1D4NA 1OQHA 1A8EA 1JQFA 1B3EA 1N7XA
chains in the KnotProt database with same CATH topology
1DTGA 3FGSA 1N84A 1FQEA 3O97A 2O7UA 1A8FA 1D3KA 1OQGA 1FQFA 1N7WA 2O84X 1D4NA 1OQHA 1A8EA 1JQFA 1B3EA 1N7XA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1DTG A;  3FGS A;  1N84 A;  1FQE A;  3O97 A;  2O7U A;  1A8F A;  1D3K A;  1OQG A;  1FQF A;  1N7W A;  2O84 X;  1D4N A;  1OQH A;  1A8E A;  1JQF A;  1B3E A;  1N7X A; 
#chains in the KnotProt database with same CATH topology
 1DTG A;  3FGS A;  1N84 A;  1FQE A;  3O97 A;  2O7U A;  1A8F A;  1D3K A;  1OQG A;  1FQF A;  1N7W A;  2O84 X;  1D4N A;  1OQH A;  1A8E A;  1JQF A;  1B3E A;  1N7X A; 
#chains in the KnotProt database with same CATH homology
 1DTG A;  3FGS A;  1N84 A;  1FQE A;  3O97 A;  2O7U A;  1A8F A;  1D3K A;  1OQG A;  1FQF A;  1N7W A;  2O84 X;  1D4N A;  1OQH A;  1A8E A;  1JQF A;  1B3E A;  1N7X A; 
1A8EA 1A8FA 1N84A 1SUVC 3S9LC 3S9MC 1BP5A 1BTJA
similar chains in the KnotProt database (40% sequence similarity)
3QYTA
similar chains in the pdb database (40% sequence similarity)

 
#similar chains in the KnotProt database (40% sequence similarity)
1A8E A; 1A8F A; 1N84 A; 1SUV C; 3S9L C; 3S9M C; 
#similar chains, but unknotted
1BTJ A; 
#similar chains in the pdb database (40% sequence similarity)
3QYT A; 

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