2O7UA

Crystal structure of k206e/k296e mutant of the n-terminal half molecule of human transferrin
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 2x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 19-161 143 1-18, 162-220 18 58 slipknot
Fingerprint Knot forming loop Loop type
K +31 Asp63 <->
Bridging ionFe500
<-> Tyr188 ... Cys331 <-> Cys137 ... Asp63
ion-based
K +31 Asp63 <->
Bridging ionFe500
<-> Tyr188 ... Cys227 <-> Cys241 ... Cys331 <-> Cys137 ... Asp63
ion-based
Chain Sequence
DKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVEHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFEDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
sequence length 329
structure length 329
publication title Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.
pubmed doi rcsb
molecule tags Metal transport
molecule keywords Serotransferrin
source organism Homo sapiens
total genus Genus: 92
ec nomenclature
pdb deposition date 2006-12-11
KnotProt deposition date 2018-11-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00405 Transferrin Transferrin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 2o7uA01
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 2o7uA02
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 2o7uA01
3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein; domain 2 Periplasmic binding protein-like II 2o7uA02
3O97A 2O7UA 1OQGA 1N84A 3FGSA 1FQEA 1DTGA 1A8EA 1A8FA 1FQFA 1JQFA 2O84X 1N7WA 1OQHA 1D4NA 1D3KA 1N7XA 1B3EA
chains in the KnotProt database with same CATH superfamily
3O97A 2O7UA 1OQGA 1N84A 3FGSA 1FQEA 1DTGA 1A8EA 1A8FA 1FQFA 1JQFA 2O84X 1N7WA 1OQHA 1D4NA 1D3KA 1N7XA 1B3EA
chains in the KnotProt database with same CATH topology
3O97A 2O7UA 1OQGA 1N84A 3FGSA 1FQEA 1DTGA 1A8EA 1A8FA 1FQFA 1JQFA 2O84X 1N7WA 1OQHA 1D4NA 1D3KA 1N7XA 1B3EA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3O97 A;  2O7U A;  1OQG A;  1N84 A;  3FGS A;  1FQE A;  1DTG A;  1A8E A;  1A8F A;  1FQF A;  1JQF A;  2O84 X;  1N7W A;  1OQH A;  1D4N A;  1D3K A;  1N7X A;  1B3E A; 
#chains in the KnotProt database with same CATH topology
 3O97 A;  2O7U A;  1OQG A;  1N84 A;  3FGS A;  1FQE A;  1DTG A;  1A8E A;  1A8F A;  1FQF A;  1JQF A;  2O84 X;  1N7W A;  1OQH A;  1D4N A;  1D3K A;  1N7X A;  1B3E A; 
#chains in the KnotProt database with same CATH homology
 3O97 A;  2O7U A;  1OQG A;  1N84 A;  3FGS A;  1FQE A;  1DTG A;  1A8E A;  1A8F A;  1FQF A;  1JQF A;  2O84 X;  1N7W A;  1OQH A;  1D4N A;  1D3K A;  1N7X A;  1B3E A; 
2O84X 3S9LC 3S9MC 1BP5A 1BTJA
similar chains in the KnotProt database (40% sequence similarity)
3QYTA 3S9NC 3V83A 3V8XB
similar chains in the pdb database (40% sequence similarity)

 
#similar chains in the KnotProt database (40% sequence similarity)
2O84 X; 3S9L C; 3S9M C; 
#similar chains, but unknotted
1BTJ A; 
#similar chains in the pdb database (40% sequence similarity)
3QYT A; 3S9N C; 3V83 A; 3V8X B; 

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