1UCHA

Deubiquitinating enzyme uch-l3 (human) at 1.8 angstrom resolution
Warning
  • Chain breaks within knot 52 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 69
Knot K -52 -31 -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-52 3-222 220 1-2, 223-226 2 4 knot
view details
-31 4-165 162 1-3 223-226 166-222 3 4 slipknot
Chain Sequence
RWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRV--------------------DLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
sequence length 226
structure length 206
publication title Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.
pubmed doi rcsb
molecule tags Cysteine protease
molecule keywords UBIQUITIN C-TERMINAL HYDROLASE UCH-L3
source organism Homo sapiens
missing residues 143-162
total genus Genus: 69
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 1997-10-06
KnotProt deposition date 2014-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Ubiquitin C-terminal Hydrolase Uch-l3 1uchA00
3IRTA 1UCHA 1XD3A 3IFWA 3KVFA 2LENA 3A7SA 1CMXA 3RIIA 4DM9A 3IHRA 2ETLA 3KW5A 3RISA
chains in the KnotProt database with same CATH superfamily
3IRTA 1UCHA 1XD3A 3IFWA 3KVFA 2LENA 3A7SA 1CMXA 3RIIA 4DM9A 3IHRA 2ETLA 3KW5A 3RISA
chains in the KnotProt database with same CATH topology
3IRTA 1UCHA 1XD3A 3IFWA 3KVFA 2LENA 3A7SA 1CMXA 3RIIA 4DM9A 3IHRA 2ETLA 3KW5A 3RISA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3IRT A;  1UCH A;  1XD3 A;  3IFW A;  3KVF A;  2LEN A;  3A7S A;  1CMX A;  3RII A;  4DM9 A;  3IHR A;  2ETL A;  3KW5 A;  3RIS A; 
#chains in the KnotProt database with same CATH topology
 3IRT A;  1UCH A;  1XD3 A;  3IFW A;  3KVF A;  2LEN A;  3A7S A;  1CMX A;  3RII A;  4DM9 A;  3IHR A;  2ETL A;  3KW5 A;  3RIS A; 
#chains in the KnotProt database with same CATH homology
 3IRT A;  1UCH A;  1XD3 A;  3IFW A;  3KVF A;  2LEN A;  3A7S A;  1CMX A;  3RII A;  4DM9 A;  3IHR A;  2ETL A;  3KW5 A;  3RIS A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling