3A7SA

Catalytic domain of uch37
Warning
  • Chain breaks within knot 52 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 59
Alphaknot: Q9Y5K5
Knot K -52 -31 -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-52 4-218 215 1-3, 219-220 3 2 knot
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-31 5-160 156 1-4 215-220 161-214 4 6 slipknot
Chain Sequence
EWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNAAATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFAR----------------AFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSD
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1m 5-144 140 1-4 148-204 145-147 4 57 slipknot
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3.1m 4-147 144 1-3 156-204 148-155 3 49 slipknot
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2.1m 4-161 158 1-3 166-204 162-165 3 39 slipknot
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3.1m 4-165 162 1-3 182-204 166-181 3 23 slipknot
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2.1m 6-185 180 1-5 198-204 186-197 5 7 slipknot
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3.1m 6-167 162 1-3, 176-204 4-5, 168-175 3 29 slipknot
sequence length 220
structure length 204
publication title Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
source organism Homo sapiens
missing residues 140-155
total genus Genus: 59
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2009-10-04
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Ubiquitin C-terminal Hydrolase Uch-l3 3a7sA00
3RISA 3RIIA 4DM9A 2LENA 3KVFA 3IHRA 1UCHA 1CMXA 1XD3A 3KW5A 3IRTA 3IFWA 2ETLA 3A7SA
chains in the KnotProt database with same CATH superfamily
3RISA 3RIIA 4DM9A 2LENA 3KVFA 3IHRA 1UCHA 1CMXA 1XD3A 3KW5A 3IRTA 3IFWA 2ETLA 3A7SA
chains in the KnotProt database with same CATH topology
3RISA 3RIIA 4DM9A 2LENA 3KVFA 3IHRA 1UCHA 1CMXA 1XD3A 3KW5A 3IRTA 3IFWA 2ETLA 3A7SA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3RIS A;  3RII A;  4DM9 A;  2LEN A;  3KVF A;  3IHR A;  1UCH A;  1CMX A;  1XD3 A;  3KW5 A;  3IRT A;  3IFW A;  2ETL A;  3A7S A; 
#chains in the KnotProt database with same CATH topology
 3RIS A;  3RII A;  4DM9 A;  2LEN A;  3KVF A;  3IHR A;  1UCH A;  1CMX A;  1XD3 A;  3KW5 A;  3IRT A;  3IFW A;  2ETL A;  3A7S A; 
#chains in the KnotProt database with same CATH homology
 3RIS A;  3RII A;  4DM9 A;  2LEN A;  3KVF A;  3IHR A;  1UCH A;  1CMX A;  1XD3 A;  3KW5 A;  3IRT A;  3IFW A;  2ETL A;  3A7S A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling