2ETLA

Crystal structure of ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
Knot K -52 -31 -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-52 5-219 215 1-4, 220-223 4 4 knot
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-31 6-163 158 1-5 217-223 164-216 5 7 slipknot
Chain Sequence
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1m 7-163 157 1-6 171-223 164-170 6 53 slipknot
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3.1m 5-183 179 1-4 194-223 184-193 4 30 slipknot
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3.1m 5-194 190 1-4 200-223 195-199 4 24 slipknot
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3.1m 9-196 188 1-8 216-223 197-215 8 8 slipknot
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3.1m 5-215 211 1-4 217-223 216-216 4 7 slipknot
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3.1m 5-216 212 1-1, 218-223 2-4, 217-217 1 6 slipknot
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2.1m 8-171 164 1-2, 177-223 3-7, 172-176 2 47 slipknot
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3.1m 8-183 176 1-4, 197-223 5-7, 184-196 4 27 slipknot
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2.1m 11-204 194 1-8, 213-223 9-10, 205-212 8 11 slipknot
sequence length 223
structure length 223
publication title Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
pubmed doi rcsb
molecule tags Hydrolase, ligase
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L1
source organism Homo sapiens
total genus Genus: 70
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2005-10-27
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Ubiquitin C-terminal Hydrolase Uch-l3 2etlA00
3KVFA 3RIIA 4DM9A 1CMXA 3IFWA 1UCHA 3KW5A 2LENA 3IHRA 1XD3A 3A7SA 3IRTA 3RISA 2ETLA
chains in the KnotProt database with same CATH superfamily
3KVFA 3RIIA 4DM9A 1CMXA 3IFWA 1UCHA 3KW5A 2LENA 3IHRA 1XD3A 3A7SA 3IRTA 3RISA 2ETLA
chains in the KnotProt database with same CATH topology
3KVFA 3RIIA 4DM9A 1CMXA 3IFWA 1UCHA 3KW5A 2LENA 3IHRA 1XD3A 3A7SA 3IRTA 3RISA 2ETLA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3KVF A;  3RII A;  4DM9 A;  1CMX A;  3IFW A;  1UCH A;  3KW5 A;  2LEN A;  3IHR A;  1XD3 A;  3A7S A;  3IRT A;  3RIS A;  2ETL A; 
#chains in the KnotProt database with same CATH topology
 3KVF A;  3RII A;  4DM9 A;  1CMX A;  3IFW A;  1UCH A;  3KW5 A;  2LEN A;  3IHR A;  1XD3 A;  3A7S A;  3IRT A;  3RIS A;  2ETL A; 
#chains in the KnotProt database with same CATH homology
 3KVF A;  3RII A;  4DM9 A;  1CMX A;  3IFW A;  1UCH A;  3KW5 A;  2LEN A;  3IHR A;  1XD3 A;  3A7S A;  3IRT A;  3RIS A;  2ETL A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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