3IHRA

Crystal structure of uch37
Warning
  • Chain breaks within knot 52 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 83
Alphaknot: Q9Y5K5
Knot K -52 -31 -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-52 5-218 214 1-4, 219-305 4 87 knot
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-31 5-160 156 1-4 215-305 161-214 4 91 slipknot
Chain Sequence
EWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFA-----------------AFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDMLSAIQSEVAKNQMLIE------EEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPL
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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5.2m 5-252 248 1-4, 253-282 4 30 knot
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2.1m 5-141 137 1-4 148-282 142-147 4 135 slipknot
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3.1m 5-147 143 1-4 153-282 148-152 4 130 slipknot
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2.1m 5-152 148 1-4 158-282 153-157 4 125 slipknot
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2.1m 5-162 158 1-4 169-282 163-168 4 114 slipknot
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3.1m 5-168 164 1-4 186-282 169-185 4 97 slipknot
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5.2m 5-201 197 1-4 252-282 202-251 4 31 slipknot
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4.4m 6-253 248 1-4, 266-282 5-5, 254-265 4 17 slipknot
sequence length 305
structure length 282
publication title Structural characterization of human Uch37.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
source organism Homo sapiens
missing residues 139-155, 243-248
total genus Genus: 83
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2009-07-30
KnotProt deposition date 2014-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Ubiquitin C-terminal Hydrolase Uch-l3 3ihrA01
3KVFA 3A7SA 3IRTA 4DM9A 1XD3A 2LENA 3IHRA 3KW5A 3RIIA 3RISA 1CMXA 3IFWA 2ETLA 1UCHA
chains in the KnotProt database with same CATH superfamily
3KVFA 3A7SA 3IRTA 4DM9A 1XD3A 2LENA 3IHRA 3KW5A 3RIIA 3RISA 1CMXA 3IFWA 2ETLA 1UCHA
chains in the KnotProt database with same CATH topology
3KVFA 3A7SA 3IRTA 4DM9A 1XD3A 2LENA 3IHRA 3KW5A 3RIIA 3RISA 1CMXA 3IFWA 2ETLA 1UCHA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3KVF A;  3A7S A;  3IRT A;  4DM9 A;  1XD3 A;  2LEN A;  3IHR A;  3KW5 A;  3RII A;  3RIS A;  1CMX A;  3IFW A;  2ETL A;  1UCH A; 
#chains in the KnotProt database with same CATH topology
 3KVF A;  3A7S A;  3IRT A;  4DM9 A;  1XD3 A;  2LEN A;  3IHR A;  3KW5 A;  3RII A;  3RIS A;  1CMX A;  3IFW A;  2ETL A;  1UCH A; 
#chains in the KnotProt database with same CATH homology
 3KVF A;  3A7S A;  3IRT A;  4DM9 A;  1XD3 A;  2LEN A;  3IHR A;  3KW5 A;  3RII A;  3RIS A;  1CMX A;  3IFW A;  2ETL A;  1UCH A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling