3KVFA

Crystal structure of the i93m mutant of ubiquitin carboxy terminal hydrolase l1 bound to ubiquitin vinylmethylester
Knot K -52 -31 -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-52 5-219 215 1-4, 220-223 4 4 knot
view details
-31 6-164 159 1-5 218-223 165-217 5 6 slipknot
Chain Sequence
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTMGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1m 6-165 160 1-5 177-223 166-176 5 47 slipknot
view details
2.1m 7-179 173 1-6 185-223 180-184 6 39 slipknot
view details
3.1m 5-184 180 1-4 196-223 185-195 4 28 slipknot
view details
3.1m 6-184 179 1-4, 194-223 5-5, 185-193 4 30 slipknot
view details
2.1m 8-201 194 1-7 215-223 202-214 7 9 slipknot
view details
3.1m 7-184 178 1-5, 193-223 6-6, 185-192 5 31 slipknot
sequence length 223
structure length 223
publication title Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation.
pubmed doi rcsb
molecule tags Hydrolase/signaling protein
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L1
source organism Homo sapiens
total genus Genus: 62
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2009-11-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Ubiquitin C-terminal Hydrolase Uch-l3 3kvfA00
3IRTA 2ETLA 4DM9A 3IFWA 1UCHA 3IHRA 1CMXA 3KVFA 3RIIA 2LENA 1XD3A 3A7SA 3RISA 3KW5A
chains in the KnotProt database with same CATH superfamily
3IRTA 2ETLA 4DM9A 3IFWA 1UCHA 3IHRA 1CMXA 3KVFA 3RIIA 2LENA 1XD3A 3A7SA 3RISA 3KW5A
chains in the KnotProt database with same CATH topology
3IRTA 2ETLA 4DM9A 3IFWA 1UCHA 3IHRA 1CMXA 3KVFA 3RIIA 2LENA 1XD3A 3A7SA 3RISA 3KW5A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3IRT A;  2ETL A;  4DM9 A;  3IFW A;  1UCH A;  3IHR A;  1CMX A;  3KVF A;  3RII A;  2LEN A;  1XD3 A;  3A7S A;  3RIS A;  3KW5 A; 
#chains in the KnotProt database with same CATH topology
 3IRT A;  2ETL A;  4DM9 A;  3IFW A;  1UCH A;  3IHR A;  1CMX A;  3KVF A;  3RII A;  2LEN A;  1XD3 A;  3A7S A;  3RIS A;  3KW5 A; 
#chains in the KnotProt database with same CATH homology
 3IRT A;  2ETL A;  4DM9 A;  3IFW A;  1UCH A;  3IHR A;  1CMX A;  3KVF A;  3RII A;  2LEN A;  1XD3 A;  3A7S A;  3RIS A;  3KW5 A; 
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling