1XEVA

Crystal structure of human carbonic anhydrase ii in a new crystal form
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-256 233 1-23, 257-259 23 3 knot
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 24-254 231 1-23, 255-259 23 5 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureHis3 <-> Lys261
... His96 <->
Bridging ionZn262
<-> His94 ... His3
probabilistic
K +31 His3 ... His96 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> His3
probabilistic
K +31 His3 ... His94 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> His3
probabilistic
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 25-255 231 1-24, 256-258 24 3 knot
view details
2.1 18-252 235 1-17 258-258 253-257 17 1 slipknot
publication title Crystal structure of human carbonic anhydrase II in a new crystal form
rcsb
structure length 258
molecule tags Lyase
source organism Homo sapiens
sequence length 258
molecule keywords Carbonic anhydrase II
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2004-09-13
KnotProt deposition date 2018-09-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 1xevA00
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 1xevA00
1BNMA 3N3JA 1KWQA 3F7UA 1ZSAA 2FMGA 1CNGA 1CVAA 1FSNA 1G4OA 2FOSA 1G52A 3IBIA 3IBUA 6CA2A 1Y7WA 3KWAA 1UGFA 1CILA 3MHOA 3F8EA 1FLJA 3DCCA 1CCUA 3DBUA 3M3XA 1FR7A 1RZDA 1BCDA 3PO6A 4CACA 3M67A 3HFPA 3M2NA 1CNCA 3MHLA 1YO2A 1CINA 2CBEA 1RZAA 1IF5A 2NN1A 1IF9A 3N4BA 3MNHA 1I9PA 2HFXA 1XEGA 9CA2A 3DA2A 3M5TA 1I91A 2HKKA 1TG3A 1LG5A 3PYKA 3BL0A 1HEBA 2WEGA 2HL4A 3B1BA 3DVBA 3IBNA 3M98A 3MDZA 1G1DA 1UGEA 3BETA 1A42A 2W2JA 1F2WA 1YDAA 3OKUA 3D0NA 3JXFA 3OKVA 3D8WA 1CVCA 1RZCA 3CAJA 3OIMA 3EFTA 3FFPX 2CBCA 2NN7A 3F7BA 1I90A 8CA2A 1XEVA 3MHMA 1I9MA 3M5EA 1YDBA 1YO1A 1TG9A 1CIMA 2Q1QA 1URTA 1CZMA 1CA2A 1KOPA 1THKA 3B4FA 2NXRA 1FSRA 1CVDA 2HFYA 2NXTA 3M5SA 2O4ZA 3MHIA 3M96A 1CANA 3CZVA 2AX2A 3KOKA 1HECA 3FW3A 2NXSA 3M40A 2EZ7A 1CRMA 1HVAA 1G0EA 1I8ZA 1IF8A 3C7PA 3CA2A 1TBTX 2NWPA 1LZVA 2HD6A 3ML2A 2WD2A 3DD8A 1HCAA 2OSFA 3EFIA 1CNXA 1CNWA 2NWYA 1BNVA 3JXHC 1FQMA 2CBBA 2X7UA 1CAJA 3M1WA 2ZNCA 1Z93A 1CNYA 1I9LA 1TEUX 1LUGA 1YDCA 3IAIA 1CRAA 2FOUA 2WEOA 1LG6A 1I9QA 1IF7A 2H15A 1DCAA 1I9OA 1RZEA 2POWA 1CNHA 3ZNCA 1BICA 1FQNA 2AW1A 1CAMA 1KWRA 1H4NA 1HEDA 1AVNA 1G4JA 1KEQA 3JXGA 3IBLA 2CA2A 1V9EA 3D93A 2ABEA 1JV0A 1JD0A 1CVFA 2GEHA 1ZNCA
chains in the KnotProt database with same CATH superfamily
1BNMA 3N3JA 1KWQA 3F7UA 1ZSAA 2FMGA 1CNGA 1CVAA 1FSNA 1G4OA 2FOSA 1G52A 3IBIA 3IBUA 6CA2A 1Y7WA 3KWAA 1UGFA 1CILA 3MHOA 3F8EA 1FLJA 3DCCA 1CCUA 3DBUA 3M3XA 1FR7A 1RZDA 1BCDA 3PO6A 4CACA 3M67A 3HFPA 3M2NA 1CNCA 3MHLA 1YO2A 1CINA 2CBEA 1RZAA 1IF5A 2NN1A 1IF9A 3N4BA 3MNHA 1I9PA 2HFXA 1XEGA 9CA2A 3DA2A 3M5TA 1I91A 2HKKA 1TG3A 1LG5A 3PYKA 3BL0A 1HEBA 2WEGA 2HL4A 3B1BA 3DVBA 3IBNA 3M98A 3MDZA 1G1DA 1UGEA 3BETA 1A42A 2W2JA 1F2WA 1YDAA 3OKUA 3D0NA 3JXFA 3OKVA 3D8WA 1CVCA 1RZCA 3CAJA 3OIMA 3EFTA 3FFPX 2CBCA 2NN7A 3F7BA 1I90A 8CA2A 1XEVA 3MHMA 1I9MA 3M5EA 1YDBA 1YO1A 1TG9A 1CIMA 2Q1QA 1URTA 1CZMA 1CA2A 1KOPA 1THKA 3B4FA 2NXRA 1FSRA 1CVDA 2HFYA 2NXTA 3M5SA 2O4ZA 3MHIA 3M96A 1CANA 3CZVA 2AX2A 3KOKA 1HECA 3FW3A 2NXSA 3M40A 2EZ7A 1CRMA 1HVAA 1G0EA 1I8ZA 1IF8A 3C7PA 3CA2A 1TBTX 2NWPA 1LZVA 2HD6A 3ML2A 2WD2A 3DD8A 1HCAA 2OSFA 3EFIA 1CNXA 1CNWA 2NWYA 1BNVA 3JXHC 1FQMA 2CBBA 2X7UA 1CAJA 3M1WA 2ZNCA 1Z93A 1CNYA 1I9LA 1TEUX 1LUGA 1YDCA 3IAIA 1CRAA 2FOUA 2WEOA 1LG6A 1I9QA 1IF7A 2H15A 1DCAA 1I9OA 1RZEA 2POWA 1CNHA 3ZNCA 1BICA 1FQNA 2AW1A 1CAMA 1KWRA 1H4NA 1HEDA 1AVNA 1G4JA 1KEQA 3JXGA 3IBLA 2CA2A 1V9EA 3D93A 2ABEA 1JV0A 1JD0A 1CVFA 2GEHA 1ZNCA
chains in the KnotProt database with same CATH topology
1BNMA 3N3JA 1KWQA 3F7UA 1ZSAA 2FMGA 1CNGA 1CVAA 1FSNA 1G4OA 2FOSA 1G52A 3IBIA 3IBUA 6CA2A 1Y7WA 3KWAA 1UGFA 1CILA 3MHOA 3F8EA 1FLJA 3DCCA 1CCUA 3DBUA 3M3XA 1FR7A 1RZDA 1BCDA 3PO6A 4CACA 3M67A 3HFPA 3M2NA 1CNCA 3MHLA 1YO2A 1CINA 2CBEA 1RZAA 1IF5A 2NN1A 1IF9A 3N4BA 3MNHA 1I9PA 2HFXA 1XEGA 9CA2A 3DA2A 3M5TA 1I91A 2HKKA 1TG3A 1LG5A 3PYKA 3BL0A 1HEBA 2WEGA 2HL4A 3B1BA 3DVBA 3IBNA 3M98A 3MDZA 1G1DA 1UGEA 3BETA 1A42A 2W2JA 1F2WA 1YDAA 3OKUA 3D0NA 3JXFA 3OKVA 3D8WA 1CVCA 1RZCA 3CAJA 3OIMA 3EFTA 3FFPX 2CBCA 2NN7A 3F7BA 1I90A 8CA2A 1XEVA 3MHMA 1I9MA 3M5EA 1YDBA 1YO1A 1TG9A 1CIMA 2Q1QA 1URTA 1CZMA 1CA2A 1KOPA 1THKA 3B4FA 2NXRA 1FSRA 1CVDA 2HFYA 2NXTA 3M5SA 2O4ZA 3MHIA 3M96A 1CANA 3CZVA 2AX2A 3KOKA 1HECA 3FW3A 2NXSA 3M40A 2EZ7A 1CRMA 1HVAA 1G0EA 1I8ZA 1IF8A 3C7PA 3CA2A 1TBTX 2NWPA 1LZVA 2HD6A 3ML2A 2WD2A 3DD8A 1HCAA 2OSFA 3EFIA 1CNXA 1CNWA 2NWYA 1BNVA 3JXHC 1FQMA 2CBBA 2X7UA 1CAJA 3M1WA 2ZNCA 1Z93A 1CNYA 1I9LA 1TEUX 1LUGA 1YDCA 3IAIA 1CRAA 2FOUA 2WEOA 1LG6A 1I9QA 1IF7A 2H15A 1DCAA 1I9OA 1RZEA 2POWA 1CNHA 3ZNCA 1BICA 1FQNA 2AW1A 1CAMA 1KWRA 1H4NA 1HEDA 1AVNA 1G4JA 1KEQA 3JXGA 3IBLA 2CA2A 1V9EA 3D93A 2ABEA 1JV0A 1JD0A 1CVFA 2GEHA 1ZNCA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1BNM A;  3N3J A;  1KWQ A;  3F7U A;  1ZSA A;  2FMG A;  1CNG A;  1CVA A;  1FSN A;  1G4O A;  2FOS A;  1G52 A;  3IBI A;  3IBU A;  6CA2 A;  1Y7W A;  3KWA A;  1UGF A;  1CIL A;  3MHO A;  3F8E A;  1FLJ A;  3DCC A;  1CCU A;  3DBU A;  3M3X A;  1FR7 A;  1RZD A;  1BCD A;  3PO6 A;  4CAC A;  3M67 A;  3HFP A;  3M2N A;  1CNC A;  3MHL A;  1YO2 A;  1CIN A;  2CBE A;  1RZA A;  1IF5 A;  2NN1 A;  1IF9 A;  3N4B A;  3MNH A;  1I9P A;  2HFX A;  1XEG A;  9CA2 A;  3DA2 A;  3M5T A;  1I91 A;  2HKK A;  1TG3 A;  1LG5 A;  3PYK A;  3BL0 A;  1HEB A;  2WEG A;  2HL4 A;  3B1B A;  3DVB A;  3IBN A;  3M98 A;  3MDZ A;  1G1D A;  1UGE A;  3BET A;  1A42 A;  2W2J A;  1F2W A;  1YDA A;  3OKU A;  3D0N A;  3JXF A;  3OKV A;  3D8W A;  1CVC A;  1RZC A;  3CAJ A;  3OIM A;  3EFT A;  3FFP X;  2CBC A;  2NN7 A;  3F7B A;  1I90 A;  8CA2 A;  1XEV A;  3MHM A;  1I9M A;  3M5E A;  1YDB A;  1YO1 A;  1TG9 A;  1CIM A;  2Q1Q A;  1URT A;  1CZM A;  1CA2 A;  1KOP A;  1THK A;  3B4F A;  2NXR A;  1FSR A;  1CVD A;  2HFY A;  2NXT A;  3M5S A;  2O4Z A;  3MHI A;  3M96 A;  1CAN A;  3CZV A;  2AX2 A;  3KOK A;  1HEC A;  3FW3 A;  2NXS A;  3M40 A;  2EZ7 A;  1CRM A;  1HVA A;  1G0E A;  1I8Z A;  1IF8 A;  3C7P A;  3CA2 A;  1TBT X;  2NWP A;  1LZV A;  2HD6 A;  3ML2 A;  2WD2 A;  3DD8 A;  1HCA A;  2OSF A;  3EFI A;  1CNX A;  1CNW A;  2NWY A;  1BNV A;  3JXH C;  1FQM A;  2CBB A;  2X7U A;  1CAJ A;  3M1W A;  2ZNC A;  1Z93 A;  1CNY A;  1I9L A;  1TEU X;  1LUG A;  1YDC A;  3IAI A;  1CRA A;  2FOU A;  2WEO A;  1LG6 A;  1I9Q A;  1IF7 A;  2H15 A;  1DCA A;  1I9O A;  1RZE A;  2POW A;  1CNH A;  3ZNC A;  1BIC A;  1FQN A;  2AW1 A;  1CAM A;  1KWR A;  1H4N A;  1HED A;  1AVN A;  1G4J A;  1KEQ A;  3JXG A;  3IBL A;  2CA2 A;  1V9E A;  3D93 A;  2ABE A;  1JV0 A;  1JD0 A;  1CVF A;  2GEH A;  1ZNC A; 
#chains in the KnotProt database with same CATH topology
 1BNM A;  3N3J A;  1KWQ A;  3F7U A;  1ZSA A;  2FMG A;  1CNG A;  1CVA A;  1FSN A;  1G4O A;  2FOS A;  1G52 A;  3IBI A;  3IBU A;  6CA2 A;  1Y7W A;  3KWA A;  1UGF A;  1CIL A;  3MHO A;  3F8E A;  1FLJ A;  3DCC A;  1CCU A;  3DBU A;  3M3X A;  1FR7 A;  1RZD A;  1BCD A;  3PO6 A;  4CAC A;  3M67 A;  3HFP A;  3M2N A;  1CNC A;  3MHL A;  1YO2 A;  1CIN A;  2CBE A;  1RZA A;  1IF5 A;  2NN1 A;  1IF9 A;  3N4B A;  3MNH A;  1I9P A;  2HFX A;  1XEG A;  9CA2 A;  3DA2 A;  3M5T A;  1I91 A;  2HKK A;  1TG3 A;  1LG5 A;  3PYK A;  3BL0 A;  1HEB A;  2WEG A;  2HL4 A;  3B1B A;  3DVB A;  3IBN A;  3M98 A;  3MDZ A;  1G1D A;  1UGE A;  3BET A;  1A42 A;  2W2J A;  1F2W A;  1YDA A;  3OKU A;  3D0N A;  3JXF A;  3OKV A;  3D8W A;  1CVC A;  1RZC A;  3CAJ A;  3OIM A;  3EFT A;  3FFP X;  2CBC A;  2NN7 A;  3F7B A;  1I90 A;  8CA2 A;  1XEV A;  3MHM A;  1I9M A;  3M5E A;  1YDB A;  1YO1 A;  1TG9 A;  1CIM A;  2Q1Q A;  1URT A;  1CZM A;  1CA2 A;  1KOP A;  1THK A;  3B4F A;  2NXR A;  1FSR A;  1CVD A;  2HFY A;  2NXT A;  3M5S A;  2O4Z A;  3MHI A;  3M96 A;  1CAN A;  3CZV A;  2AX2 A;  3KOK A;  1HEC A;  3FW3 A;  2NXS A;  3M40 A;  2EZ7 A;  1CRM A;  1HVA A;  1G0E A;  1I8Z A;  1IF8 A;  3C7P A;  3CA2 A;  1TBT X;  2NWP A;  1LZV A;  2HD6 A;  3ML2 A;  2WD2 A;  3DD8 A;  1HCA A;  2OSF A;  3EFI A;  1CNX A;  1CNW A;  2NWY A;  1BNV A;  3JXH C;  1FQM A;  2CBB A;  2X7U A;  1CAJ A;  3M1W A;  2ZNC A;  1Z93 A;  1CNY A;  1I9L A;  1TEU X;  1LUG A;  1YDC A;  3IAI A;  1CRA A;  2FOU A;  2WEO A;  1LG6 A;  1I9Q A;  1IF7 A;  2H15 A;  1DCA A;  1I9O A;  1RZE A;  2POW A;  1CNH A;  3ZNC A;  1BIC A;  1FQN A;  2AW1 A;  1CAM A;  1KWR A;  1H4N A;  1HED A;  1AVN A;  1G4J A;  1KEQ A;  3JXG A;  3IBL A;  2CA2 A;  1V9E A;  3D93 A;  2ABE A;  1JV0 A;  1JD0 A;  1CVF A;  2GEH A;  1ZNC A; 
#chains in the KnotProt database with same CATH homology
 1BNM A;  3N3J A;  1KWQ A;  3F7U A;  1ZSA A;  2FMG A;  1CNG A;  1CVA A;  1FSN A;  1G4O A;  2FOS A;  1G52 A;  3IBI A;  3IBU A;  6CA2 A;  1Y7W A;  3KWA A;  1UGF A;  1CIL A;  3MHO A;  3F8E A;  1FLJ A;  3DCC A;  1CCU A;  3DBU A;  3M3X A;  1FR7 A;  1RZD A;  1BCD A;  3PO6 A;  4CAC A;  3M67 A;  3HFP A;  3M2N A;  1CNC A;  3MHL A;  1YO2 A;  1CIN A;  2CBE A;  1RZA A;  1IF5 A;  2NN1 A;  1IF9 A;  3N4B A;  3MNH A;  1I9P A;  2HFX A;  1XEG A;  9CA2 A;  3DA2 A;  3M5T A;  1I91 A;  2HKK A;  1TG3 A;  1LG5 A;  3PYK A;  3BL0 A;  1HEB A;  2WEG A;  2HL4 A;  3B1B A;  3DVB A;  3IBN A;  3M98 A;  3MDZ A;  1G1D A;  1UGE A;  3BET A;  1A42 A;  2W2J A;  1F2W A;  1YDA A;  3OKU A;  3D0N A;  3JXF A;  3OKV A;  3D8W A;  1CVC A;  1RZC A;  3CAJ A;  3OIM A;  3EFT A;  3FFP X;  2CBC A;  2NN7 A;  3F7B A;  1I90 A;  8CA2 A;  1XEV A;  3MHM A;  1I9M A;  3M5E A;  1YDB A;  1YO1 A;  1TG9 A;  1CIM A;  2Q1Q A;  1URT A;  1CZM A;  1CA2 A;  1KOP A;  1THK A;  3B4F A;  2NXR A;  1FSR A;  1CVD A;  2HFY A;  2NXT A;  3M5S A;  2O4Z A;  3MHI A;  3M96 A;  1CAN A;  3CZV A;  2AX2 A;  3KOK A;  1HEC A;  3FW3 A;  2NXS A;  3M40 A;  2EZ7 A;  1CRM A;  1HVA A;  1G0E A;  1I8Z A;  1IF8 A;  3C7P A;  3CA2 A;  1TBT X;  2NWP A;  1LZV A;  2HD6 A;  3ML2 A;  2WD2 A;  3DD8 A;  1HCA A;  2OSF A;  3EFI A;  1CNX A;  1CNW A;  2NWY A;  1BNV A;  3JXH C;  1FQM A;  2CBB A;  2X7U A;  1CAJ A;  3M1W A;  2ZNC A;  1Z93 A;  1CNY A;  1I9L A;  1TEU X;  1LUG A;  1YDC A;  3IAI A;  1CRA A;  2FOU A;  2WEO A;  1LG6 A;  1I9Q A;  1IF7 A;  2H15 A;  1DCA A;  1I9O A;  1RZE A;  2POW A;  1CNH A;  3ZNC A;  1BIC A;  1FQN A;  2AW1 A;  1CAM A;  1KWR A;  1H4N A;  1HED A;  1AVN A;  1G4J A;  1KEQ A;  3JXG A;  3IBL A;  2CA2 A;  1V9E A;  3D93 A;  2ABE A;  1JV0 A;  1JD0 A;  1CVF A;  2GEH A;  1ZNC A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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