|
K 2.1
|
|
7e3sA
|
Crystal structure of trml from shewanella oneidensis
|
|
K 2.1
|
|
7e3qA
|
Crystal structure of sah bound trml from vibrio vulnificus
|
|
K 2.1
|
|
7d51A
|
Crystal structure of a truly knotted protein: cyclized yibk from haemophilus influenzae
|
|
K 2.1
|
|
7mu3A
|
Human carbonic anhydrase 9 mimic with compound
|
|
K 2.1
|
|
6zr9A
|
The crystal structure of the complex of hcavii with 2-(4-benzhydrylpiperazin-1-yl)-n-(4-sulfamoylphenyl)acetamide
|
|
K 2.1
|
|
6ymaA
|
Microed structure of acetazolamide-bound human carbonic anhydrase ii
|
|
K 2.1
|
|
6ufdA
|
Carbonic anhydrase 2 with inhibitor (2z)-3-oxo-n-(4-sulfamoylphenyl)-2-[(thiophen-2-yl)methylidene]butanamide (11g/d7)
|
|
K 2.1
|
|
6ufcA
|
Carbonic anhydrase 2 with inhibitor (2z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-n-(4-sulfamoylphenyl)butanamide (11d/d4)
|
|
K 2.1
|
|
6km6A
|
Human carbonic anhydrase ii native 15 atm co2
|
|
K 2.1
|
|
6wq7A
|
Carbonic anhydrase ii complexed with 2-((3-aminopropyl)(phenethyl)amino)-n-(4-fluorobenzyl)-n-(4-sulfamoylphenethyl)acetamide
|
|
K 2.1
|
|
6wq8A
|
Carbonic anhydrase ii complexed with 3-((2-((furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid
|
|
K 2.1
|
|
6otkA
|
Carbonic anhydrase ix mimic complexed with ureido benzene sulfonamide mb10-596b
|
|
K 2.1
|
|
6otiA
|
Carbonic anhydrase ix mimic complexed with ureic benzene sulfonamide mb9-561b
|
|
K 2.1
|
|
6oumA
|
Carbonic anhydrase ix mimic complexed with benzene sulfonamide mb10-580b
|
|
K 2.1
|
|
6oueA
|
Carbonic anhydrase ii complexed with benzene sulfonamide mb11-707a
|
|
K 2.1
|
|
6rg3A
|
Crystal structure of human carbonic anhydrase ii in complex with (r)-4-(2-benzylpiperazin-1-yl)benzenesulfonamide
|
|
K 2.1
|
|
6s03A
|
Carbonic anhydrase caix mimic in complex with inhibitor i39lt379
|
|
K 2.1
|
|
6ux1A
|
Carbonic anhydrase ii complexed with salicylic acid
|
|
K 2.1
|
|
6r6jA
|
Crystal structure of human carbonic anhydrase isozyme ii with 2-(benzenesulfonyl)-4-chloro-n-(2-hydroxyethyl)-5-sulfamoyl-benzamide
|
|
K 2.1
|
1
|
6rxzCN
|
Cryo-em structure of the 90s pre-ribosome (kre33-noc4) from chaetomium thermophilum, state b
|
|
K 2.1
|
|
6qutA
|
Three dimensional structure of human carbonic anhydrase ix in complex with benzenesulfonamide
|
|
K 2.1
|
|
6i0jA
|
Crystal structure of human carbonic anhydrase i in complex with the 4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl sulfamate inhibitor
|
|
K 2.1
|
|
6i0lA
|
Crystal structure of human carbonic anhydrase i in complex with the 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[2-(4-sulfamoylphenyl)ethyl]urea inhibitor
|
|
K 2.1
|
|
6qfvA
|
Human carbonic anhydrase ii with bound ircp* complex (cofactor 8) to generate an artificial transfer hydrogenase (athase)
|
|
K 2.1
|
|
6qfxA
|
Human carbonic anhydrase ii with bound ircp* complex (cofactor 10) to generate an artificial transfer hydrogenase (athase)
|
|
K 2.1
|
|
6qfuA
|
Human carbonic anhydrase ii with bound ircp* complex (cofactor 7) to generate an artificial transfer hydrogenase (athase)
|
|
K 2.1
|
|
6qfwA
|
Human carbonic anhydrase ii with bound ircp* complex (cofactor 9) to generate an artificial transfer hydrogenase (athase)
|
|
K 2.1
|
|
6qebA
|
Assessment of a large enzyme-drug complex by proton-detected solid-state nmr without deuteration
|
|
K 2.1
|
|
6h2zA
|
The crystal structure of human carbonic anhydrase ii in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.
|
|
K 2.1
|
|
6h34A
|
The crystal structure of human carbonic anhydrase ii in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
|
|
K 2.1
|
|
6h33A
|
The crystal structure of human carbonic anhydrase ii in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide.
|
|
K 2.1
|
|
6g3vA
|
Crystal structure of human carbonic anhydrase i in complex with the inhibitor famotidine
|
|
K 2.1
|
|
12caA
|
Altering the mouth of a hydrophobic pocket. structure and kinetics of human carbonic anhydrase ii mutants at residue val-121
|
|
K 2.1
|
|
5e2mA
|
Crystal structure of human carbonic anhydrase isozyme i with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
|
|
K 2.1
|
|
6evrA
|
Crystal structure of human carbonic anhydrase i in complex with the 4-(4 acetyl-3-benzylpiperazine-1 carbonyl)benzene-1-sulfonamide inhibitor
|
|
K 2.1
|
|
1azmA
|
Drug-protein interactions: structure of sulfonamide drug complexed with human carbonic anhydrase i
|
|
K 2.1
|
|
1cvbA
|
Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase ii
|
|
K 2.1
|
|
7ca2A
|
Engineering the hydrophobic pocket of carbonic anhydrase ii
|
|
K 2.1
|
|
3mwoA
|
Human carbonic anhydrase ii in a doubled monoclinic cell: a re-determination
|
|
K 2.1
|
|
1yddA
|
Structural basis of inhibitor affinity to variants of human carbonic anhydrase ii
|
|
K 2.1
|
|
1huhA
|
Differences in anionic inhibition of human carbonic anhydrase i revealed from the structures of iodide and gold cyanide inhibitor complexes
|
|
K 2.1
|
|
1hugA
|
Differences in anionic inhibition of human carbonic anhydrase i revealed from the structures of iodide and gold cyanide inhibitor complexes
|
|
K 2.1
|
|
3p44A
|
Human carbonic anhydrase ii in complex with p-(4-ruthenocenyl-1h-1,2,3-triazol-1-yl)benzenesulfonamide
|
|
K 2.1
|
|
3bl1A
|
Carbonic anhydrase inhibitors. sulfonamide diuretics revisited old leads for new applications
|
|
K 2.1
|
|
4g7aA
|
The crystal structure of an alpha carbonic anhydrase from the extremophilic bacterium sulfurihydrogenibium yellowstonense yo3aop1
|
|
K 2.1
|
|
3w6iA
|
Crystal structure of 19f probe-labeled hcai
|
|
K 2.1
|
|
1cveA
|
Structural consequences of redesigning a protein-zinc binding site
|
|
K 2.1
|
|
1hcbA
|
Enzyme-substrate interactions: structure of human carbonic anhydrase i complexed with bicarbonate
|
|
K 2.1
|
|
4mtyA
|
Structure at 1a resolution of a helical aromatic foldamer-protein complex.
|
|
K 2.1
|
|
5tfxA
|
New method for synthesis of benzoxazole amide inhibitors of carbonic anhydrase
|
|
K 2.1
|
|
4l5vA
|
The structural implications of the secondary co2 binding pocket in human carbonic anhydrase ii
|
|
K 2.1
|
|
3kkxA
|
Neutron structure of human carbonic anhydrase ii
|
|
K 2.1
|
|
4pq7A
|
The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
|
|
K 2.1
|
|
1rj5A
|
Crystal structure of the extracellular domain of murine carbonic anhydrase xiv
|
|
K 2.1
|
|
2fw4A
|
Carbonic anhydrase activators. the first x-ray crystallographic study of an activator of isoform i, structure with l-histidine.
|
|
K 2.1
|
|
1bnqA
|
Carbonic anhydrase ii inhibitor
|
|
K 2.1
|
|
2eu3A
|
Human carbonic anhydrase ii in complex with novel inhibitors
|
|
K 2.1
|
|
2wehA
|
Thermodynamic optimisation of carbonic anhydrase fragment inhibitors
|
|
K 2.1
|
|
3f4xA
|
Carbonic anhydrase inhibitors. comparison of chlorthalidone and indapamide x-ray crystal structures in adducts with isozyme ii: when three water molecules make the difference
|
|
K 2.1
|
|
3ieoA
|
The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
|
|
K 2.1
|
|
4m2wA
|
Genetically engineered carbonic anhydrase ix in complex with dorzolamide
|
|
K 2.1
|
|
4ywpA
|
Sucrose binding site in genetically engineered carbonic anhydrase ix
|
|
K 2.1
|
|
4q08A
|
Crystal structure of chimeric carbonic anhydrase xii with inhibitor
|
|
K 2.1
|
|
4xixA
|
Carbonic anhydrase cah3 from chlamydomonas reinhardtii in complex with phosphate.
|
|
K 2.1
|
|
1j9wA
|
Solution structure of the cai michigan 1 variant
|
|
K 2.1
|
|
5ty1A
|
Identification of a new zinc binding chemotype by fragment screening
|
|
K 2.1
|
|
5eheA
|
Crystal structure of human carbonic anhydrase isozyme ii with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
|
|
K 2.1
|
|
5ogjA
|
Crystal structure of human carbonic anhydrase isozyme xiii with 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide
|
|
K 2.1
|
|
4bcwA
|
Carbonic anhydrase ix mimic in complex with (e)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid
|
|
K 2.1
|
|
1ccsA
|
Structure-assisted redesign of a protein-zinc binding site with femtomolar affinity
|
|
K 2.1
|
|
3t82A
|
Human carbonic anhydrase ii in complex with acetylated carbohydrate sulfamates
|
|
K 2.1
|
|
1ugaA
|
Human carbonic anhydrase ii[hcaii] (e.c.4.2.1.1) mutant with ala 65 replaced by phe (a65f)
|
|
K 2.1
|
|
1fqrA
|
X-ray crystal structure of cobalt-bound f93i/f95m/w97v carbonic anhydrase (caii) variant
|
|
K 2.1
|
|
3ni5A
|
Carbonic anhydrase inhibitor: c1 family
|
|
K 2.1
|
|
1bnwA
|
Carbonic anhydrase ii inhibitor
|
|
K 2.1
|
|
4e4aA
|
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
|
|
K 2.1
|
|
5n1sA
|
Crystal structure of human carbonic anhydrase ii in complex with the inhibitor 4-(1h-indol-2-yl)-benzenesulfonamide
|
|
K 2.1
|
|
5cacA
|
Refined structure of human carbonic anhydrase ii at 2.0 angstroms resolution
|
|
K 2.1
|
|
5tyaA
|
Identification of a new zinc binding chemotype by fragment screening
|
|
K 2.1
|
|
2povA
|
The crystal structure of the human carbonic anhydrase ii in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide
|
|
K 2.1
|
|
4wl4A
|
Crystal structure of human carbonic anhydrase ii in complex with the 6-hydroxy-chromene-2-thione inhibitor
|
|
K 2.1
|
|
4itoA
|
Human ca ii inhibition by novel sulfonamide
|
|
K 2.1
|
|
3v3jA
|
Kinetic and structural studies of thermostabilized mutants of hca ii.
|
|
K 2.1
|
|
4fl7A
|
The crystal structure of human carbonic anhydrase ii in complex with n-(hydroxy)-benzamide
|
|
K 2.1
|
|
1koqA
|
Neisseria gonorrhoeae carbonic anhydrase
|
|
K 2.1
|
|
1cvhA
|
Structural consequences of redesigning a protein-zinc binding site
|
|
K 2.1
|
|
2it4A
|
X ray structure of the complex between carbonic anhydrase i and the phosphonate antiviral drug foscarnet
|
|
K 2.1
|
|
1g6vA
|
Complex of the camelid heavy-chain antibody fragment cab-ca05 with bovine carbonic anhydrase
|
|
K 2.1
|
|
1rj6A
|
Crystal structure of the extracellular domain of murine carbonic anhydrase xiv in complex with acetazolamide
|
|
K 2.1
|
|
1cctA
|
Structure-assisted redesign of a protein-zinc binding site with femtomolar affinity
|
|
K 2.1
|
|
1bnuA
|
Carbonic anhydrase ii inhibitor
|
|
K 2.1
|
|
3m2zA
|
Fragment tethered to carbonic anhydrase ii h64c mutant
|
|
K 2.1
|
|
6bccA
|
Joint x-ray/neutron structure of human carbonic anhydrase ii in complex with ethoxzolamide
|
|
K 2.1
|
|
1dcbA
|
Structure of an engineered metal binding site in human carbonic anhydrase ii reveals the architecture of a regulatory cysteine switch
|
|
K 2.1
|
|
4frcA
|
Carbonic anhydrase ii in complex with n'-sulfamoylpyrrolidine-1-carboximidamide
|
|
K 2.1
|
|
1oq5A
|
Carbonic anhydrase ii in complex with nanomolar inhibitor
|
|
K 2.1
|
|
4e3dA
|
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
|
|
K 2.1
|
|
4pxxA
|
Crystal structure of a highly thermal stabilized variant of human carbonic anhydrase ii
|
|
K 2.1
|
|
4r5bA
|
Human carbonic anhydrase ii in complex with a carbohydrate-based sulfamate
|
|
K 2.1
|
|
3dcsA
|
Use of carbonic anhydrase ii, ix active-site mimic, for the purpose of screening inhibitors for possible anti-cancer properties
|
|
K 2.1
|
|
2cabA
|
Structure, refinement and function of carbonic anhydrase isozymes. refinement of human carbonic anhydrase i
|
|
K 2.1
|
|
4q6dA
|
Crystal structure of human carbonic anhydrase isozyme ii with 4-[(z)-azepan-1-yldiazenyl]benzenesulfonamide
|
|
K 2.1
|
|
5u0eA
|
Identification of a new zinc binding chemotype by fragment screening
|
|
K 2.1
|
|
1dcaA
|
Structure of an engineered metal binding site in human carbonic anhydrase ii reveals the architecture of a regulatory cysteine switch
|
|
K 2.1
|
|
4qjxA
|
Crystal structure of human carbonic anhydrase isozyme xiii with inhibitor
|
|
K 2.1
|
|
5gmmA
|
Crystal structure of human carbonic anhydrase i in complex with polmacoxib
|
|
K 2.1
|
|
4yvyA
|
Crystal structure of human carbonic anhydrase ii in complex with hydroxylamine-o-sulfonamide, a molecule incorporating two zinc-binding groups.
|
|
K 2.1
|
|
5n0dA
|
Crystal structure of human carbonic anhydrase ii in complex with (r)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1h-2-carbonyl)benzenesulfonamide.
|
|
K 2.1
|
|
1cvaA
|
Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase ii
|
|
K 2.1
|
|
1cilA
|
The positions of his-64 and a bound water in human carbonic anhydrase ii upon binding three structurally related inhibitors
|
|
K 2.1
|
|
1tg9A
|
Effect of shuttle location and ph environment on h+ transfer in human carbonic anhydrase ii
|
|
K 2.1
|
|
1hecA
|
Structural consequences of hydrophilic amino-acid substitutions in the hydrophobic pocket of human carbonic anhydrase ii
|
|
K 2.1
|
|
1cvcA
|
Redesigning the zinc binding site of human carbonic anhydrase ii: structure of a his2asp-zn2+ metal coordination polyhedron
|
|
K 2.1
|
|
1yo1A
|
Proton transfer from his200 in human carbonic anhydrase ii
|
|
K 2.1
|
|
2nxsA
|
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase ii
|
|
K 2.1
|
|
1ydbA
|
Structural basis of inhibitor affinity to variants of human carbonic anhydrase ii
|
|
K 2.1
|
|
2nxrA
|
Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase ii
|
|
K 2.1
|
|
3t84A
|
Human carbonic anhydrase ii in complex with acetylated carbohydrate sulfamates
|
|
K 2.1
|
|
4z1jA
|
Carbonic anhydrase inhibitors: design and synthesis of new heteroaryl-n-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hca vii, hca ix, and hca xiv)
|
|
K 2.1
|
|
4y0jA
|
H/d exchanged human carbonic anhydrase ii ph 6 room temperature neutron crystal structure.
|
|
K 2.1
|
|
1fr7A
|
X-ray crystal structure of zinc-bound f93s/f95l/w97m carbonic anhydrase (caii) variant
|
|
K 2.1
|
|
1crmA
|
Structure and function of carbonic anhydrases
|
|
K 2.1
|
|
1fljA
|
Crystal structure of s-glutathiolated carbonic anhydrase iii
|
|
K 2.1
|
|
1cnwA
|
Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase ii influence binding constants
|
|
K 2.1
|
|
4q06A
|
Crystal structure of chimeric carbonic anhydrase ix with inhibitor
|
|
K 2.1
|
|
2nn7A
|
Structure of inhibitor binding to carbonic anhydrase i
|
|
K 2.1
|
|
3m5sA
|
Carbonic anhydrase ii mutant h64c in complex with carbonate
|
|
K 2.1
|
|
3m1wA
|
Carbonic anhyrdase ii mutant w5ch64c with closed disulfide bond in complex with sulfate
|
|
K 2.1
|
|
1cvdA
|
Structural consequences of redesigning a protein-zinc binding site
|
|
K 2.1
|
|
6d1mA
|
Design, synthesis, and x-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
|
|
K 2.1
|
|
1fsrA
|
X-ray crystal structure of copper-bound f93s/f95l/w97m carbonic anhydrase (caii) variant
|
|
K 2.1
|
|
4m2vA
|
Genetically engineered carbonic anhydrase ix in complex with brinzolamide
|
|
K 2.1
|
|
4k1qA
|
Structure of hcaix mimic (hcaii with 5 mutations in active site)
|
|
K 2.1
|
|
1cnyA
|
Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase ii influence binding constants
|
|
K 2.1
|
|
1a42A
|
Human carbonic anhydrase ii complexed with brinzolamide
|
|
K 2.1
|
|
3v3gB
|
Kinetic and structural studies of thermostabilized mutants of hca ii.
|
|
K 2.1
|
|
3hfpA
|
Crystal structure of teh complex between ca ii and the activator mai
|
|
K 2.1
|
|
1cncA
|
Compensatory plastic effects in the redesign of protein-zinc binding sites
|
|
K 2.1
|
|
2nwzA
|
Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase ii
|
|
K 2.1
|
|
4hf3A
|
Activity enhancers of h64a variant of human carbonic anhydrase ii possess multiple binding sites within and around the enzyme structure
|
|
K 2.1
|
|
3tvoX
|
Human carbonic anhydrase ii proton transfer double mutant
|
|
K 2.1
|
|
2q38A
|
Carbonic anhydrase ii in complex with saccharin at 1.95 angstrom
|
|
K 2.1
|
|
3kigA
|
Mutant carbonic anhydrase ii in complex with an azide and an alkyne
|
|
K 2.1
|
|
3m2yA
|
Carbonic anhydrase ii in complex with novel sulfonamide inhibitor
|
|
K 2.1
|
|
8ca2A
|
Engineering the hydrophobic pocket of carbonic anhydrase ii
|
|
K 2.1
|
|
3da2A
|
X-ray structure of human carbonic anhydrase 13 in complex with inhibitor
|
|
K 2.1
|
|
4yytA
|
Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (5).
|
|
K 2.1
|
|
4yxoA
|
Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (3).
|
|
K 2.1
|
|
2h15A
|
Carbonic anhydrase inhibitors: clashing with ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme ii
|
|
K 2.1
|
|
1cimA
|
The positions of his-64 and a bound water in human carbonic anhydrase ii upon binding three structurally related inhibitors
|
