S +31
|
S 3x +31
|
|
4n0xB
|
Room temperature crystal structure of human carbonic anhydrase ii in complex with thiophene-2-sulfonamide
|
S +31
|
S 3x +31
|
|
3mnaA
|
The crystal structure of human carbonic anhydrase ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor
|
S +31
|
S 3x +31
|
|
4knjA
|
Crystal structure of human carbonic anhydrase isozyme ii with 2-chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide
|
S +31
|
S 5x +31
|
|
1ccsA
|
Structure-assisted redesign of a protein-zinc binding site with femtomolar affinity
|
S +31
|
S 3x +31
|
|
5bu6A
|
Structure of bpsb deaceylase domain from bordetella bronchiseptica
|
S +31
|
S 15x +31
|
|
4q7pA
|
Crystal structure of 1-hydroxy-3-methylpyridine-2(1h)-thione bound to hcaii
|
S +31
|
S 11x +31
|
|
1bn1A
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 3x +31
|
|
4k0zA
|
Structure of hcaix mimic (hcaii with 5 mutations in active site) in complex with methazolamide
|
S +31
|
S 3x +31
|
|
5fnlA
|
Native state mass spectrometry, surface plasmon resonance and x-ray crystallography correlate strongly as a fragment screening combination
|
S +31
|
S 11x +31
|
|
4yxiA
|
Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (2).
|
S +31
|
S 7x +31
|
|
2hocA
|
Crystal structure of the human carbonic anhydrase ii in complex with the 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide inhibitor
|
S +31
|
S 5x +31
|
|
1cniA
|
X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site
|
S +31
|
S 12x -31
|
|
3wbhA
|
Structural characteristics of alkaline phosphatase from a moderately halophilic bacteria halomonas sp.593
|
S +31
|
S 3x +31
|
|
5eheA
|
Crystal structure of human carbonic anhydrase isozyme ii with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
|
S +31
|
S 3x +31
|
|
1j9wA
|
Solution structure of the cai michigan 1 variant
|
S +31
|
S 3x +31
|
|
3mzcA
|
Human carbonic ahydrase ii in complex with a benzenesulfonamide inhibitor
|
S +31
|
S 3x +31
|
|
4k0sA
|
Structure of hcaix mimic (hcaii with 5 mutations in active site) in complex with acetazolamide
|
S +31
|
S 3x +31
|
|
5cluA
|
The crystal structure of the complex of hcaii with a saccharine derivative
|
S +31
|
S 3x +31
|
|
4k0tA
|
Structure of hcaix mimic (hcaii with 5 mutations in active site) in complex with chlorzolamide
|
S +31
|
S 3x +31
|
|
3w6hA
|
Crystal structure of 19f probe-labeled hcai in complex with acetazolamide
|
S +31
|
S 3x +31
|
|
5fnhA
|
Native state mass spectrometry, surface plasmon resonance and x-ray crystallography correlate strongly as a fragment screening combination
|
S +31
|
S 23x +31
|
|
1if4A
|
Carbonic anhydrase ii complexed with 4-fluorobenzenesulfonamide
|
S +31
|
S 15x +31
|
|
1i9nA
|
Carbonic anhydrase ii (f131v) complexed with 4-(aminosulfonyl)-n-[(2,5-difluorophenyl)methyl]-benzamide
|
S +31
|
S 15x +31
|
|
1if6A
|
Carbonic anhydrase ii complexed with 3,5-difluorobenzenesulfonamide
|
S +31
|
S 7x +31
|
|
1g46A
|
Carbonic anhydrase ii (f131v) complexed with 4-(aminosulfonyl)-n-[(2,3-difluorophenyl)methyl]-benzamide
|
S +31
|
S 3x +31
|
|
6ekiA
|
Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney
|
S +31
|
S 3x +31
|
|
3igpA
|
Structure of inhibitor binding to carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
5ogpA
|
Metalacarborane inhibitors of carbonic anhydrase ix
|
S +31
|
S 3x +31
|
|
4xixA
|
Carbonic anhydrase cah3 from chlamydomonas reinhardtii in complex with phosphate.
|
S +31
|
S 3x +31
|
|
4q09A
|
Crystal structure of chimeric carbonic anhydrase xii with inhibitor
|
S +31
|
S 3x +31
|
|
4e3hA
|
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
|
S +31
|
S 3x +31
|
|
4m2wA
|
Genetically engineered carbonic anhydrase ix in complex with dorzolamide
|
S +31
|
S 3x +31
|
|
4q08A
|
Crystal structure of chimeric carbonic anhydrase xii with inhibitor
|
S +31
|
S 3x +31
|
|
4q07A
|
Crystal structure of chimeric carbonic anhydrase ix with inhibitor
|
S +31
|
S 3x +31
|
|
3r17B
|
Hcarbonic anhydrase ii bound to n-(2-fluoro.4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
|
S +31
|
S 10x +31
|
|
4ca2A
|
Engineering the hydrophobic pocket of carbonic anhydrase ii
|
S +31
|
S 6x +31
|
|
3ieoA
|
The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
|
S +31
|
S 11x +31
|
|
3nj9A
|
Crystal structure of carbonic anhydrase ii in complex with a nir inhibitor
|
S +31
|
S 3x +31
|
|
2cbdA
|
Structure of native and apo carbonic anhydrase ii and some of its anion-ligand complexes
|
S +31
|
S 3x +31
|
|
3f4xA
|
Carbonic anhydrase inhibitors. comparison of chlorthalidone and indapamide x-ray crystal structures in adducts with isozyme ii: when three water molecules make the difference
|
S +31
|
S 3x +31
|
|
2wehA
|
Thermodynamic optimisation of carbonic anhydrase fragment inhibitors
|
S +31
|
S 3x +31
|
4
|
2nnvA
|
Structure of inhibitor binding to carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
2fw4A
|
Carbonic anhydrase activators. the first x-ray crystallographic study of an activator of isoform i, structure with l-histidine.
|
S +31
|
S 3x +31
|
|
3dc9A
|
Use of carbonic anhydrase ii, ix active-site mimic, for the purpose of screening inhibitors for possible anti-cancer properties
|
S +31
|
S 7x +31
|
|
1g3zA
|
Carbonic anhydrase ii (f131v)
|
S +31
|
S 3x +31
|
|
1zscA
|
Carbonic anhydrase ii mutant e117q, holo form
|
S +31
|
S 11x +31
|
|
1bn3A
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 3x +31
|
|
2cbaA
|
Structure of native and apo carbonic anhydrase ii and some of its anion-ligand complexes
|
S +31
|
S 3x +31
|
|
1rj5A
|
Crystal structure of the extracellular domain of murine carbonic anhydrase xiv
|
S +31
|
S 3x +31
|
|
2eu3A
|
Human carbonic anhydrase ii in complex with novel inhibitors
|
S +31
|
S 7x +31
|
|
1bnqA
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 3x +31
|
|
3mnkA
|
Human carbonic anhydrase ii mutant k170h
|
S +31
|
S 3x +31
|
|
5jepB
|
Human carbonic anhydrase ii (t199s) complexed with benzo[d]thiazole-2-sulfonamide
|
S +31
|
S 3x +31
|
|
4qk3A
|
Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase ii - [delta]230-240
|
S +31
|
S 3x +31
|
|
5ekhA
|
Human carbonic anhydrase ii complexed with a two-faced guest
|
S +31
|
S 7x +31
|
|
4xe1A
|
Human carbonic anhydrase ii in complex with 6-sulfamoyl-saccharin
|
S +31
|
S 3x +31
|
|
5eh5A
|
Human carbonic anhydrase ii in complex with ligand
|
S +31
|
S 3x +31
|
|
4rn4A
|
Human carbonic anhydrases ii in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety
|
S +31
|
S 3x +31
|
|
4pq7A
|
The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
|
S +31
|
S 3x +31
|
|
3hljA
|
Crystal structure of human carbonic anhydrase isozyme ii with 3-methylthiobenzimidazo[1,2-c][1,2,3]thiadiazol-7-sulfonamide
|
S +31
|
S 3x +31
|
|
3oikA
|
Human carbonic anhydrase ii mutant a65s, n67q (ca ix mimic) bound by 2-ethylestradiol 3,17-o,o-bis-sulfamate
|
S +31
|
S 3x +31
|
|
3mnjA
|
Human carbonic anhydrase ii mutant k170e
|
S +31
|
S 3x +31
|
4
|
2x7sA
|
Structures of human carbonic anhydrase ii inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
|
S +31
|
S 15x +31
|
|
4mtyA
|
Structure at 1a resolution of a helical aromatic foldamer-protein complex.
|
S +31
|
S 3x +31
|
|
1hcbA
|
Enzyme-substrate interactions: structure of human carbonic anhydrase i complexed with bicarbonate
|
S +31
|
S 3x +31
|
|
3mniA
|
Human carbonic anhydrase ii mutant k170d
|
S +31
|
S 7x +31
|
|
5fdiA
|
Crystal structure of human carbonic anhydrase ii with the anticonvulsant sulfamide jnj-26990990 and its s,s-dioxide analog.
|
S +31
|
S 3x +31
|
4
|
2nngA
|
Structure of inhibitor binding to carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
6b5aA
|
Carbonic anhydrase ix-mimic in complex with nitrogenous base-bearing benezenesulfonamide
|
S +31
|
S 24x -31
|
|
5kgnA
|
1.95a resolution structure of independent phosphoglycerate mutase from c. elegans in complex with a macrocyclic peptide inhibitor (2d)
|
S +31
|
S 1x +31
|
|
1cveA
|
Structural consequences of redesigning a protein-zinc binding site
|
S +31
|
S 3x +31
|
|
3w6iA
|
Crystal structure of 19f probe-labeled hcai
|
S +31
|
S 3x +31
|
4
|
2foqA
|
Human carbonic anhydrase ii complexed with two-prong inhibitors
|
S +31
|
S 3x +31
|
|
5bu6B
|
Structure of bpsb deaceylase domain from bordetella bronchiseptica
|
S +31
|
S 11x +31
|
|
1bn4A
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 3x +31
|
|
4q49A
|
Room temperature neutron crystal structure of apo human carbonic anhydrase at ph 7.5
|
S +31
|
S 3x +31
|
|
1yo0A
|
Proton transfer from his200 in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
4zwzA
|
Engineered carbonic anhydrase ix mimic in complex with a glucosyl sulfamate inhibitor
|
S +31
|
S 11x +31
|
|
1heaA
|
Carbonic anhydrase ii (carbonate dehydratase) (hca ii) (e.c.4.2.1.1) mutant with leu 198 replaced by arg (l198r)
|
S +31
|
S 3x +31
|
|
3ryvB
|
Carbonic anhydrase complexed with n-ethyl-4-sulfamoylbenzamide
|
S +31
|
S 3x +31
|
|
4g7aA
|
The crystal structure of an alpha carbonic anhydrase from the extremophilic bacterium sulfurihydrogenibium yellowstonense yo3aop1
|
S +31
|
S 3x +31
|
|
5txyA
|
Identification of a new zinc binding chemotype of by fragment screening on human carbonic anhydrase
|
S +31
|
S 3x +31
|
|
1te3X
|
Effect of shuttle location and ph environment on h+ transfer in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
4k13A
|
Structure of hcaix mimic (hcaii with 5 mutations in active site) in complex with dorzolamide
|
S +31
|
S 11x +31
|
|
1fqlA
|
X-ray crystal structure of zinc-bound f95m/w97v carbonic anhydrase (caii) variant
|
S +31
|
S 3x +31
|
|
1hugA
|
Differences in anionic inhibition of human carbonic anhydrase i revealed from the structures of iodide and gold cyanide inhibitor complexes
|
S +31
|
S 3x +31
|
|
3rz1B
|
Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the hydrophobic wall of carbonic anhydrase
|
S +31
|
S 3x +31
|
4
|
3fe4A
|
Crystal structure of human carbonic anhydrase vi
|
S +31
|
S 3x +31
|
|
3bl1A
|
Carbonic anhydrase inhibitors. sulfonamide diuretics revisited old leads for new applications
|
S +31
|
S 3x +31
|
|
3p44A
|
Human carbonic anhydrase ii in complex with p-(4-ruthenocenyl-1h-1,2,3-triazol-1-yl)benzenesulfonamide
|
S +31
|
S 3x +31
|
|
4z1nA
|
Carbonic anhydrase inhibitors: design and synthesis of new heteroaryl-n-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hca vii, hca ix, and hca xiv)
|
S +31
|
S 3x +31
|
|
1lgdA
|
Crystal structure analysis of hca ii mutant t199p in complex with bicarbonate
|
S +31
|
S 7x +31
|
|
7ca2A
|
Engineering the hydrophobic pocket of carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1huhA
|
Differences in anionic inhibition of human carbonic anhydrase i revealed from the structures of iodide and gold cyanide inhibitor complexes
|
S +31
|
S 3x +31
|
|
5fnjA
|
Native state mass spectrometry, surface plasmon resonance and x-ray crystallography correlate strongly as a fragment screening combination
|
S +31
|
S 3x +31
|
|
6equA
|
X-ray crystal structure of the human carbonic anhydrase ii adduct with a membrane-impermeant inhibitor
|
S +31
|
S 11x +31
|
|
1yddA
|
Structural basis of inhibitor affinity to variants of human carbonic anhydrase ii
|
S +31
|
S 11x +31
|
|
2gd8A
|
Crystal structure analysis of the human carbonic anhydrase ii in complex with a 2-substituted estradiol bis-sulfamate
|
S +31
|
S 3x +31
|
|
3mwoA
|
Human carbonic anhydrase ii in a doubled monoclinic cell: a re-determination
|
S +31
|
S 3x +31
|
|
5e2sA
|
Crystal structure of human carbonic anhydrase ii in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor
|
S +31
|
S 3x +31
|
|
1cvbA
|
Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
4pyyA
|
Crystal structure of human carbonic anhydrase isozyme ii with inhibitor
|
S +31
|
S 3x +31
|
|
4dz7A
|
Hca ii in complex with novel sulfonamide inhibitors set d
|
S +31
|
S 15x +31
|
|
4q81A
|
Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1h)-thione bound to human carbonic anhydrase ii
|
S +31
|
S 6x +31
|
|
1dcaA
|
Structure of an engineered metal binding site in human carbonic anhydrase ii reveals the architecture of a regulatory cysteine switch
|
S +31
|
S 3x +31
|
|
4heyA
|
Activity enhancers of h64a variant of human carbonic anhydrase ii possess multiple binding sites within and around the enzyme structure
|
S +31
|
S 7x +31
|
|
1g45A
|
Carbonic anhydrase ii (f131v) complexed with 4-(aminosulfonyl)-n-[(2-fluorophenyl)methyl]-benzamide
|
S +31
|
S 22x +31
|
|
1bntA
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 11x +31
|
|
1muaA
|
Structure and energetics of a non-proline cis-peptidyl linkage in an engineered protein
|
S +31
|
S 11x +31
|
|
4jssA
|
Human carbonic anhydrase ii h94d bound to a bidentate inhibitor
|
S +31
|
S 3x +31
|
|
2cabA
|
Structure, refinement and function of carbonic anhydrase isozymes. refinement of human carbonic anhydrase i
|
S +31
|
S 15x +31
|
|
4js6A
|
Crystal structure of inhibitor-free hcaii h94d
|
S +31
|
S 3x +31
|
|
5ehvA
|
Human carbonic anhydrase ii in complex with ligand
|
S +31
|
S 3x +31
|
|
2vvaX
|
Human carbonic anhydrase in complex with co2
|
S +31
|
S 3x +31
|
|
1bzmA
|
Drug-protein interactions: structure of sulfonamide drug complexed with human carbonic anhydrase i
|
S +31
|
S 3x +31
|
|
4q6dA
|
Crystal structure of human carbonic anhydrase isozyme ii with 4-[(z)-azepan-1-yldiazenyl]benzenesulfonamide
|
S +31
|
S 3x +31
|
|
5amlA
|
Three dimensional structure of human carbonic anhydrase ii in complex with 2-(but-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid
|
S +31
|
S 15x +31
|
|
1am6A
|
Carbonic anhydrase ii inhibitor: acetohydroxamate
|
S +31
|
S 3x +31
|
|
5eh8A
|
Human carbonic anhydrase ii in complex with ligand
|
S +31
|
S 3x +31
|
|
5e2nA
|
Crystal structure of human carbonic anhydrase isozyme xiii with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
|
S +31
|
S 3x +31
|
|
3dcsA
|
Use of carbonic anhydrase ii, ix active-site mimic, for the purpose of screening inhibitors for possible anti-cancer properties
|
S +31
|
S 15x +31
|
|
1g53A
|
Carbonic anhydrase ii complexed with 4-(aminosulfonyl)-n-[(2,6-difluorophenyl)methyl]-benzamide
|
S +31
|
S 3x +31
|
|
5fl6A
|
Three dimensional structure of human carbonic anhydrase ix in complex with 5-(1-(4-methylphenyl)-1h-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
|
S +31
|
S 3x +31
|
|
4lhiA
|
Crystal structure of human carbonic anhydrase isozyme ii with 5-(phenylsulfonyl)thiophene-2-sulfonamide
|
S +31
|
S 3x +31
|
|
3oyqA
|
Structure of human carbonic anhydrase ii complexed with 5,6-dihydro-benzo[h]cinnolin-3-ylamine
|
S +31
|
S 3x +31
|
|
1eouA
|
Crystal structure of human carbonic anhydrase ii complexed with an anticonvulsant sugar sulfamate
|
S +31
|
S 3x +31
|
|
4zaoA
|
Genetically engineered carbonic anhydrase ix
|
S +31
|
S 3x +31
|
|
1oq5A
|
Carbonic anhydrase ii in complex with nanomolar inhibitor
|
S +31
|
S 23x +31
|
|
4frcA
|
Carbonic anhydrase ii in complex with n'-sulfamoylpyrrolidine-1-carboximidamide
|
S +31
|
S 11x +31
|
|
4yx4A
|
Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (1).
|
S +31
|
S 3x +31
|
|
5fniA
|
Native state mass spectrometry, surface plasmon resonance and x-ray crystallography correlate strongly as a fragment screening combination
|
S +31
|
S 3x +31
|
|
4r5bA
|
Human carbonic anhydrase ii in complex with a carbohydrate-based sulfamate
|
S +31
|
S 3x +31
|
|
1rayA
|
The structure of human carbonic anhydrase ii in complex with bromide and azide
|
S +31
|
S 3x +31
|
|
1caiA
|
Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3m5tA
|
Fragment tethered to carbonic anhydrase ii h64c mutant
|
S +31
|
S 3x +31
|
|
4pxxA
|
Crystal structure of a highly thermal stabilized variant of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
4e3dA
|
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
|
S +31
|
S 3x +31
|
|
3n2pA
|
Crystal structure of human carbonic anhydrase ii in complex with a benzenesulfonamide inhibitor
|
S +31
|
S 3x +31
|
|
3t5zA
|
Crystal structure of the human carbonic anhydrase ii in complex with n-methoxy-benzenesulfonamide
|
S +31
|
S 3x +31
|
|
1dcbA
|
Structure of an engineered metal binding site in human carbonic anhydrase ii reveals the architecture of a regulatory cysteine switch
|
S +31
|
S 3x +31
|
|
3s9tA
|
Crystal structure of human carbonic anhydrase isozyme ii with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide
|
S +31
|
S 3x +31
|
|
6bccA
|
Joint x-ray/neutron structure of human carbonic anhydrase ii in complex with ethoxzolamide
|
S +31
|
S 3x +31
|
|
5dsjA
|
Structure of co2 released holo-form of human carbonic anhydrase ii with 50 sec warming
|
S +31
|
S 7x +31
|
|
1g48A
|
Carbonic anhydrase ii (f131v) complexed with 4-(aminosulfonyl)-n-[(2,6-difluorophenyl)methyl]-benzamide
|
S +31
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S 3x +31
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5ti0A
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Crystal structure of 2-hydroxycyclohepta-2,4,6-triene-1-thione bound to human carbonic anhydrase 2 l198g
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S +31
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S 3x +31
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3hkqA
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Human carbonic anhydrase ii in complex with 1-s-d-galactopyranosylsulfonamide
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S +31
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S 3x +31
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5jn7A
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Carbonic anhydrase ii in complex with u-ch3
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S +31
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S 3x +31
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4qjwA
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Crystal structure of catalytic domain of human carbonic anhydrase isozyme xii with inhibitor
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S +31
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S 7x +31
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4q7vA
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Crystal structure of 1-hydroxy-5-methylpyridine-2(1h)-thione bound to human carbonic anhydrase ii
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S +31
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S 3x +31
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1cayA
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Wild-type and e106q mutant carbonic anhydrase complexed with acetate
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