1MXAA

S-adenosylmethionine synthetase with ppi
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 124
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 17-265 249 1-16, 266-383 16 118 knot
Chain Sequence
AKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPD------RADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 18-270 253 1-17 335-377 271-334 17 43 slipknot
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1.1 18-236 219 1-4, 249-377 5-17, 237-248 4 129 slipknot
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2.1 19-360 342 361-377 1-4 5-18 4 16 slipknot
sequence length 383
structure length 377
publication title Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-ADENOSYLMETHIONINE SYNTHETASE
missing residues 102-107
total genus Genus: 124
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 1996-01-10
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1mxaA03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1mxaA02
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1mxaA01
1MXBA 1P7LA 1RG9A 1MXAA 1XRAA 2OBVA 1XRBA 2P02A 1O92A 1XRCA 1O9TA 1FUGA 3IMLA 1QM4A 1O90A 1MXCA 1O93A
chains in the KnotProt database with same CATH superfamily
1MXBA 1P7LA 1RG9A 1MXAA 1XRAA 2OBVA 1XRBA 2P02A 1O92A 1XRCA 1O9TA 1FUGA 3IMLA 1QM4A 1O90A 1MXCA 1O93A
chains in the KnotProt database with same CATH topology
1MXBA 1P7LA 1RG9A 1MXAA 1XRAA 2OBVA 1XRBA 2P02A 1O92A 1XRCA 1O9TA 1FUGA 3IMLA 1QM4A 1O90A 1MXCA 1O93A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1MXB A;  1P7L A;  1RG9 A;  1MXA A;  1XRA A;  2OBV A;  1XRB A;  2P02 A;  1O92 A;  1XRC A;  1O9T A;  1FUG A;  3IML A;  1QM4 A;  1O90 A;  1MXC A;  1O93 A; 
#chains in the KnotProt database with same CATH topology
 1MXB A;  1P7L A;  1RG9 A;  1MXA A;  1XRA A;  2OBV A;  1XRB A;  2P02 A;  1O92 A;  1XRC A;  1O9T A;  1FUG A;  3IML A;  1QM4 A;  1O90 A;  1MXC A;  1O93 A; 
#chains in the KnotProt database with same CATH homology
 1MXB A;  1P7L A;  1RG9 A;  1MXA A;  1XRA A;  2OBV A;  1XRB A;  2P02 A;  1O92 A;  1XRC A;  1O9T A;  1FUG A;  3IML A;  1QM4 A;  1O90 A;  1MXC A;  1O93 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling