1MXBA

S-adenosylmethionine synthetase with adp
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 17-266 250 1-16, 267-383 16 117 knot
Chain Sequence
AKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPD------RADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 19-266 248 1-18 335-377 267-334 18 43 slipknot
view details
2.1 18-354 337 355-377 1-4 5-17 4 22 slipknot
view details
1.1 18-236 219 1-6, 247-377 7-17, 237-246 6 131 slipknot
view details
1.1 18-344 327 1-6, 355-377 7-17, 345-354 6 23 slipknot
sequence length 383
structure length 377
publication title Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-ADENOSYLMETHIONINE SYNTHETASE
missing residues 102-107
total genus Genus: 125
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 1996-01-10
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1mxbA03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1mxbA02
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1mxbA01
1O92A 1XRBA 1MXCA 3IMLA 1O90A 1O93A 1FUGA 1O9TA 1MXBA 1P7LA 1QM4A 1XRAA 1XRCA 1MXAA 2OBVA 2P02A 1RG9A
chains in the KnotProt database with same CATH superfamily
1O92A 1XRBA 1MXCA 3IMLA 1O90A 1O93A 1FUGA 1O9TA 1MXBA 1P7LA 1QM4A 1XRAA 1XRCA 1MXAA 2OBVA 2P02A 1RG9A
chains in the KnotProt database with same CATH topology
1O92A 1XRBA 1MXCA 3IMLA 1O90A 1O93A 1FUGA 1O9TA 1MXBA 1P7LA 1QM4A 1XRAA 1XRCA 1MXAA 2OBVA 2P02A 1RG9A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1O92 A;  1XRB A;  1MXC A;  3IML A;  1O90 A;  1O93 A;  1FUG A;  1O9T A;  1MXB A;  1P7L A;  1QM4 A;  1XRA A;  1XRC A;  1MXA A;  2OBV A;  2P02 A;  1RG9 A; 
#chains in the KnotProt database with same CATH topology
 1O92 A;  1XRB A;  1MXC A;  3IML A;  1O90 A;  1O93 A;  1FUG A;  1O9T A;  1MXB A;  1P7L A;  1QM4 A;  1XRA A;  1XRC A;  1MXA A;  2OBV A;  2P02 A;  1RG9 A; 
#chains in the KnotProt database with same CATH homology
 1O92 A;  1XRB A;  1MXC A;  3IML A;  1O90 A;  1O93 A;  1FUG A;  1O9T A;  1MXB A;  1P7L A;  1QM4 A;  1XRA A;  1XRC A;  1MXA A;  2OBV A;  2P02 A;  1RG9 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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