1O92A

Methionine adenosyltransferase complexed with adp and a l-methionine analogous
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 119
Alphaknot: P13444
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 15-271 257 1-14, 272-380 14 109 knot
Chain Sequence
GAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP------------EDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 19-273 255 1-2, 338-368 3-18, 274-337 2 31 slipknot
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1.1 14-342 329 1-3, 356-368 4-13, 343-355 3 13 slipknot
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1.1 18-342 325 1-13, 356-368 14-17, 343-355 13 13 slipknot
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2.1 20-358 339 359-368 1-5 6-19 5 9 slipknot
sequence length 380
structure length 368
publication title Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-ADENOSYLMETHIONINE SYNTHETASE
source organism Rattus norvegicus
missing residues 101-112
total genus Genus: 119
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 2002-12-10
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1o92A01
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1o92A03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1o92A02
2P02A 3IMLA 2OBVA 1FUGA 1MXBA 1O93A 1QM4A 1O9TA 1O90A 1XRBA 1O92A 1XRCA 1MXCA 1RG9A 1P7LA 1MXAA 1XRAA
chains in the KnotProt database with same CATH superfamily
2P02A 3IMLA 2OBVA 1FUGA 1MXBA 1O93A 1QM4A 1O9TA 1O90A 1XRBA 1O92A 1XRCA 1MXCA 1RG9A 1P7LA 1MXAA 1XRAA
chains in the KnotProt database with same CATH topology
2P02A 3IMLA 2OBVA 1FUGA 1MXBA 1O93A 1QM4A 1O9TA 1O90A 1XRBA 1O92A 1XRCA 1MXCA 1RG9A 1P7LA 1MXAA 1XRAA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2P02 A;  3IML A;  2OBV A;  1FUG A;  1MXB A;  1O93 A;  1QM4 A;  1O9T A;  1O90 A;  1XRB A;  1O92 A;  1XRC A;  1MXC A;  1RG9 A;  1P7L A;  1MXA A;  1XRA A; 
#chains in the KnotProt database with same CATH topology
 2P02 A;  3IML A;  2OBV A;  1FUG A;  1MXB A;  1O93 A;  1QM4 A;  1O9T A;  1O90 A;  1XRB A;  1O92 A;  1XRC A;  1MXC A;  1RG9 A;  1P7L A;  1MXA A;  1XRA A; 
#chains in the KnotProt database with same CATH homology
 2P02 A;  3IML A;  2OBV A;  1FUG A;  1MXB A;  1O93 A;  1QM4 A;  1O9T A;  1O90 A;  1XRB A;  1O92 A;  1XRC A;  1MXC A;  1RG9 A;  1P7L A;  1MXA A;  1XRA A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling