2P02A

Crystal structure of the alpha subunit of human s-adenosylmethionine synthetase 2
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 15-270 256 1-14, 271-380 14 110 knot
Chain Sequence
GTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 18-277 260 1-3, 349-380 4-17, 278-348 3 32 slipknot
view details
2.1 18-367 350 368-380 1-4 5-17 4 12 slipknot
view details
1.1 17-265 249 1-5, 277-380 6-16, 266-276 5 104 slipknot
view details
1.1 18-352 335 1-6, 366-380 7-17, 353-365 6 15 slipknot
sequence length 380
structure length 380
publication title Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2
rcsb
molecule tags Transferase
molecule keywords S-adenosylmethionine synthetase isoform type-2
source organism Homo sapiens
total genus Genus: 142
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 2007-02-28
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 2p02A03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 2p02A01
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 2p02A02
2OBVA 1O9TA 1RG9A 2P02A 1O92A 3IMLA 1O90A 1MXCA 1O93A 1P7LA 1MXBA 1MXAA 1QM4A 1FUGA 1XRAA 1XRBA 1XRCA
chains in the KnotProt database with same CATH superfamily
2OBVA 1O9TA 1RG9A 2P02A 1O92A 3IMLA 1O90A 1MXCA 1O93A 1P7LA 1MXBA 1MXAA 1QM4A 1FUGA 1XRAA 1XRBA 1XRCA
chains in the KnotProt database with same CATH topology
2OBVA 1O9TA 1RG9A 2P02A 1O92A 3IMLA 1O90A 1MXCA 1O93A 1P7LA 1MXBA 1MXAA 1QM4A 1FUGA 1XRAA 1XRBA 1XRCA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 2OBV A;  1O9T A;  1RG9 A;  2P02 A;  1O92 A;  3IML A;  1O90 A;  1MXC A;  1O93 A;  1P7L A;  1MXB A;  1MXA A;  1QM4 A;  1FUG A;  1XRA A;  1XRB A;  1XRC A; 
#chains in the KnotProt database with same CATH topology
 2OBV A;  1O9T A;  1RG9 A;  2P02 A;  1O92 A;  3IML A;  1O90 A;  1MXC A;  1O93 A;  1P7L A;  1MXB A;  1MXA A;  1QM4 A;  1FUG A;  1XRA A;  1XRB A;  1XRC A; 
#chains in the KnotProt database with same CATH homology
 2OBV A;  1O9T A;  1RG9 A;  2P02 A;  1O92 A;  3IML A;  1O90 A;  1MXC A;  1O93 A;  1P7L A;  1MXB A;  1MXA A;  1QM4 A;  1FUG A;  1XRA A;  1XRB A;  1XRC A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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