1XRAA

Crystal structure of s-adenosylmethionine synthetase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 17-266 250 1-16, 267-383 16 117 knot
Chain Sequence
AKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPD------RADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 18-273 256 1-17 339-377 274-338 17 39 slipknot
view details
1.1 17-253 237 1-3, 274-377 4-16, 254-273 3 104 slipknot
view details
2.1 18-355 338 356-377 1-4 5-17 4 21 slipknot
sequence length 383
structure length 377
publication title Crystal structure of S-adenosylmethionine synthetase.
pubmed doi rcsb
molecule tags Methyltransferase
molecule keywords S-ADENOSYLMETHIONINE SYNTHETASE
missing residues 102-107
total genus Genus: 129
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 1995-10-26
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1xraA03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1xraA02
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1xraA01
2OBVA 1O9TA 1RG9A 2P02A 1O92A 3IMLA 1O90A 1MXCA 1O93A 1P7LA 1MXBA 1MXAA 1QM4A 1FUGA 1XRAA 1XRBA 1XRCA
chains in the KnotProt database with same CATH superfamily
2OBVA 1O9TA 1RG9A 2P02A 1O92A 3IMLA 1O90A 1MXCA 1O93A 1P7LA 1MXBA 1MXAA 1QM4A 1FUGA 1XRAA 1XRBA 1XRCA
chains in the KnotProt database with same CATH topology
2OBVA 1O9TA 1RG9A 2P02A 1O92A 3IMLA 1O90A 1MXCA 1O93A 1P7LA 1MXBA 1MXAA 1QM4A 1FUGA 1XRAA 1XRBA 1XRCA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 2OBV A;  1O9T A;  1RG9 A;  2P02 A;  1O92 A;  3IML A;  1O90 A;  1MXC A;  1O93 A;  1P7L A;  1MXB A;  1MXA A;  1QM4 A;  1FUG A;  1XRA A;  1XRB A;  1XRC A; 
#chains in the KnotProt database with same CATH topology
 2OBV A;  1O9T A;  1RG9 A;  2P02 A;  1O92 A;  3IML A;  1O90 A;  1MXC A;  1O93 A;  1P7L A;  1MXB A;  1MXA A;  1QM4 A;  1FUG A;  1XRA A;  1XRB A;  1XRC A; 
#chains in the KnotProt database with same CATH homology
 2OBV A;  1O9T A;  1RG9 A;  2P02 A;  1O92 A;  3IML A;  1O90 A;  1MXC A;  1O93 A;  1P7L A;  1MXB A;  1MXA A;  1QM4 A;  1FUG A;  1XRA A;  1XRB A;  1XRC A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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