1QM4A

Methionine adenosyltransferase complexed with a l-methionine analogous
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 114
Alphaknot: P13444
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 17-277 261 1-16, 278-380 16 103 knot
Chain Sequence
GAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP------------EDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 6-237 232 1-5 246-368 238-245 5 123 slipknot
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2.1 18-269 252 1-17 337-368 270-336 17 32 slipknot
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2.1 19-356 338 357-368 1-4 5-18 4 11 slipknot
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1.1 15-237 223 1-5, 246-368 6-14, 238-245 5 123 slipknot
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1.1 18-343 326 1-6, 356-368 7-17, 344-355 6 13 slipknot
sequence length 380
structure length 368
publication title The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site
pubmed doi rcsb
molecule tags Transferase
molecule keywords METHIONINE ADENOSYLTRANSFERASE, ALPHA FORM
source organism Rattus norvegicus
missing residues 101-112
total genus Genus: 114
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 1999-09-20
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1qm4A01
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1qm4A03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1qm4A02
1MXBA 1P7LA 1RG9A 1MXAA 1XRAA 2OBVA 1XRBA 2P02A 1O92A 1XRCA 1O9TA 1FUGA 3IMLA 1QM4A 1O90A 1MXCA 1O93A
chains in the KnotProt database with same CATH superfamily
1MXBA 1P7LA 1RG9A 1MXAA 1XRAA 2OBVA 1XRBA 2P02A 1O92A 1XRCA 1O9TA 1FUGA 3IMLA 1QM4A 1O90A 1MXCA 1O93A
chains in the KnotProt database with same CATH topology
1MXBA 1P7LA 1RG9A 1MXAA 1XRAA 2OBVA 1XRBA 2P02A 1O92A 1XRCA 1O9TA 1FUGA 3IMLA 1QM4A 1O90A 1MXCA 1O93A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1MXB A;  1P7L A;  1RG9 A;  1MXA A;  1XRA A;  2OBV A;  1XRB A;  2P02 A;  1O92 A;  1XRC A;  1O9T A;  1FUG A;  3IML A;  1QM4 A;  1O90 A;  1MXC A;  1O93 A; 
#chains in the KnotProt database with same CATH topology
 1MXB A;  1P7L A;  1RG9 A;  1MXA A;  1XRA A;  2OBV A;  1XRB A;  2P02 A;  1O92 A;  1XRC A;  1O9T A;  1FUG A;  3IML A;  1QM4 A;  1O90 A;  1MXC A;  1O93 A; 
#chains in the KnotProt database with same CATH homology
 1MXB A;  1P7L A;  1RG9 A;  1MXA A;  1XRA A;  2OBV A;  1XRB A;  2P02 A;  1O92 A;  1XRC A;  1O9T A;  1FUG A;  3IML A;  1QM4 A;  1O90 A;  1MXC A;  1O93 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling