1XRBA

S-adenosylmethionine synthetase (mat, atp: l-methionine s-adenosyltransferase, e.c.2.5.1.6) in which met residues are replaced with selenomethionine residues (mse)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 119
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 17-266 250 1-16, 267-383 16 117 knot
Chain Sequence
AKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPD------RADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 19-270 252 1-3, 340-377 4-18, 271-339 3 38 slipknot
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1.1 16-339 324 1-4, 358-377 5-15, 340-357 4 20 slipknot
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2.1 20-358 339 359-377 1-5 6-19 5 18 slipknot
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1.1 18-237 220 1-6, 248-377 7-17, 238-247 6 130 slipknot
sequence length 383
structure length 377
publication title Crystal structure of S-adenosylmethionine synthetase.
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-ADENOSYLMETHIONINE SYNTHETASE
missing residues 102-107
total genus Genus: 119
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 1995-10-26
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1xrbA03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1xrbA01
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1xrbA02
1O92A 1O93A 2OBVA 1MXAA 1MXCA 1RG9A 1FUGA 1P7LA 3IMLA 1XRBA 2P02A 1O90A 1O9TA 1XRCA 1QM4A 1MXBA 1XRAA
chains in the KnotProt database with same CATH superfamily
1O92A 1O93A 2OBVA 1MXAA 1MXCA 1RG9A 1FUGA 1P7LA 3IMLA 1XRBA 2P02A 1O90A 1O9TA 1XRCA 1QM4A 1MXBA 1XRAA
chains in the KnotProt database with same CATH topology
1O92A 1O93A 2OBVA 1MXAA 1MXCA 1RG9A 1FUGA 1P7LA 3IMLA 1XRBA 2P02A 1O90A 1O9TA 1XRCA 1QM4A 1MXBA 1XRAA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1O92 A;  1O93 A;  2OBV A;  1MXA A;  1MXC A;  1RG9 A;  1FUG A;  1P7L A;  3IML A;  1XRB A;  2P02 A;  1O90 A;  1O9T A;  1XRC A;  1QM4 A;  1MXB A;  1XRA A; 
#chains in the KnotProt database with same CATH topology
 1O92 A;  1O93 A;  2OBV A;  1MXA A;  1MXC A;  1RG9 A;  1FUG A;  1P7L A;  3IML A;  1XRB A;  2P02 A;  1O90 A;  1O9T A;  1XRC A;  1QM4 A;  1MXB A;  1XRA A; 
#chains in the KnotProt database with same CATH homology
 1O92 A;  1O93 A;  2OBV A;  1MXA A;  1MXC A;  1RG9 A;  1FUG A;  1P7L A;  3IML A;  1XRB A;  2P02 A;  1O90 A;  1O9T A;  1XRC A;  1QM4 A;  1MXB A;  1XRA A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling