1O9TA

Methionine adenosyltransferase complexed with both substrates atp and methionine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 17-277 261 1-16, 278-380 16 103 knot
Chain Sequence
GAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP------------EDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 19-272 254 1-18 338-368 273-337 18 31 slipknot
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1.1 17-237 221 1-4, 247-368 5-16, 238-246 4 122 slipknot
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1.1 18-340 323 1-4, 354-368 5-17, 341-353 4 15 slipknot
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1.1 18-353 336 1-4, 355-368 5-17, 354-354 4 14 slipknot
view details
2.1 19-354 336 355-368 1-4 5-18 4 13 slipknot
sequence length 380
structure length 368
publication title Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism
pubmed doi rcsb
molecule tags Transferase
molecule keywords S-ADENOSYLMETHIONINE SYNTHETASE
source organism Rattus norvegicus
missing residues 101-112
total genus Genus: 119
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 2002-12-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1o9tA01
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1o9tA03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1o9tA02
1XRAA 1MXBA 1QM4A 1O93A 1XRCA 1MXAA 1P7LA 3IMLA 1XRBA 1RG9A 1O9TA 1MXCA 1O92A 2P02A 1O90A 1FUGA 2OBVA
chains in the KnotProt database with same CATH superfamily
1XRAA 1MXBA 1QM4A 1O93A 1XRCA 1MXAA 1P7LA 3IMLA 1XRBA 1RG9A 1O9TA 1MXCA 1O92A 2P02A 1O90A 1FUGA 2OBVA
chains in the KnotProt database with same CATH topology
1XRAA 1MXBA 1QM4A 1O93A 1XRCA 1MXAA 1P7LA 3IMLA 1XRBA 1RG9A 1O9TA 1MXCA 1O92A 2P02A 1O90A 1FUGA 2OBVA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1XRA A;  1MXB A;  1QM4 A;  1O93 A;  1XRC A;  1MXA A;  1P7L A;  3IML A;  1XRB A;  1RG9 A;  1O9T A;  1MXC A;  1O92 A;  2P02 A;  1O90 A;  1FUG A;  2OBV A; 
#chains in the KnotProt database with same CATH topology
 1XRA A;  1MXB A;  1QM4 A;  1O93 A;  1XRC A;  1MXA A;  1P7L A;  3IML A;  1XRB A;  1RG9 A;  1O9T A;  1MXC A;  1O92 A;  2P02 A;  1O90 A;  1FUG A;  2OBV A; 
#chains in the KnotProt database with same CATH homology
 1XRA A;  1MXB A;  1QM4 A;  1O93 A;  1XRC A;  1MXA A;  1P7L A;  3IML A;  1XRB A;  1RG9 A;  1O9T A;  1MXC A;  1O92 A;  2P02 A;  1O90 A;  1FUG A;  2OBV A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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