1QM4A

Methionine adenosyltransferase complexed with a l-methionine analogous
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 17-277 261 1-16, 278-380 16 103 knot
Chain Sequence
GAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP------------EDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 6-237 232 1-5 246-368 238-245 5 123 slipknot
view details
2.1 18-269 252 1-17 337-368 270-336 17 32 slipknot
view details
2.1 19-356 338 357-368 1-4 5-18 4 11 slipknot
view details
1.1 15-237 223 1-5, 246-368 6-14, 238-245 5 123 slipknot
view details
1.1 18-343 326 1-6, 356-368 7-17, 344-355 6 13 slipknot
missing residues 101-112
publication title The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site
pubmed doi rcsb
structure length 368
molecule tags Transferase
source organism Rattus norvegicus
sequence length 380
total genus Genus: 114
molecule keywords METHIONINE ADENOSYLTRANSFERASE, ALPHA FORM
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 1999-09-20
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1qm4A01
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1qm4A03
3.30.300.10 Alpha Beta 2-Layer Sandwich GMP Synthetase; Chain A, domain 3 GMP Synthetase; Chain A, domain 3 1qm4A02
1P7LA 2OBVA 1MXBA 2P02A 1XRCA 1MXAA 3IMLA 1O92A 1RG9A 1FUGA 1O93A 1O9TA 1XRAA 1O90A 1MXCA 1XRBA 1QM4A
chains in the KnotProt database with same CATH superfamily
1P7LA 2OBVA 1MXBA 2P02A 1XRCA 1MXAA 3IMLA 1O92A 1RG9A 1FUGA 1O93A 1O9TA 1XRAA 1O90A 1MXCA 1XRBA 1QM4A
chains in the KnotProt database with same CATH topology
1P7LA 2OBVA 1MXBA 2P02A 1XRCA 1MXAA 3IMLA 1O92A 1RG9A 1FUGA 1O93A 1O9TA 1XRAA 1O90A 1MXCA 1XRBA 1QM4A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1P7L A;  2OBV A;  1MXB A;  2P02 A;  1XRC A;  1MXA A;  3IML A;  1O92 A;  1RG9 A;  1FUG A;  1O93 A;  1O9T A;  1XRA A;  1O90 A;  1MXC A;  1XRB A;  1QM4 A; 
#chains in the KnotProt database with same CATH topology
 1P7L A;  2OBV A;  1MXB A;  2P02 A;  1XRC A;  1MXA A;  3IML A;  1O92 A;  1RG9 A;  1FUG A;  1O93 A;  1O9T A;  1XRA A;  1O90 A;  1MXC A;  1XRB A;  1QM4 A; 
#chains in the KnotProt database with same CATH homology
 1P7L A;  2OBV A;  1MXB A;  2P02 A;  1XRC A;  1MXA A;  3IML A;  1O92 A;  1RG9 A;  1FUG A;  1O93 A;  1O9T A;  1XRA A;  1O90 A;  1MXC A;  1XRB A;  1QM4 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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