| Knot core range | Knot core length | Knot tails range | Slipknot tails range | Slipknot loops range | N-end length | C-end length | Type | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| view details |
 | +31 | 5-117 | 113 | 1-4 | 305-329 | 118-304 | 4 | 25 | slipknot |
Chain Sequence |
MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSG---------------PRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
|
| sequence length |
329
|
| structure length |
314
|
| publication title |
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
pubmed doi rcsb |
| molecule tags |
Transferase
|
| molecule keywords |
Thymidine kinase
|
| source organism |
Human herpesvirus 1
|
| missing residues |
220-234
|
| ec nomenclature |
ec 2.7.1.21: Thymidine kinase. |
| pdb deposition date | 2011-04-01 |
| KnotProt deposition date | 2014-08-18 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00693 | Herpes_TK | Thymidine kinase from herpesvirus |
Image from the rcsb pdb (www.rcsb.org)cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases |
#chains in the KnotProt database with same CATH superfamily 3RDP A; 1E2N A; 1KI6 A; 4IVP A; 1VTK A; 1KI6 B; 3F0T A; 1E2H A; 1KI4 A; 1QHI A; 1OF1 A; 4JBX A; 1E2I A; 1KI3 A; 1P75 A; 2VTK A; 1F48 A; 1E2L A; 1KI8 A; 4IVR A; 1E2P A; 4JBY A; 1E2J A; 1KI2 A; 1P72 A; 1E2K A; 1P7C A; 2KI5 A; 1E2M A; 1KI7 A; 4IVQ A; 1KIM A; 1P6X A; 1OSN A; 1P73 A; 3VTK A; #chains in the KnotProt database with same CATH topology 3RDP A; 3M4N A; 3FSG A; 3L04 A; 1E2N A; 1KI6 A; 4IVP A; 3KZK A; 1QMG A; 3KZC A; 3L02 A; 2FG7 C; 1VTK A; 4JBX A; 3FR8 A; 2FG6 C; 2G7M C; 1KI6 B; 3F0T A; 1LNS A; 1E2H A; 1KI4 A; 1JS1 X; 3KZM A; 3M5D A; 3FR7 A; 1QHI A; 1YRL A; 1OF1 A; 3M5C A; 3L05 A; 4IVR A; 1E2I A; 1KI3 A; 1P75 A; 2VTK A; 1YH1 A; 1F48 A; 1YVE I; 1E2L A; 1KI8 A; 3M4J A; 2XTJ A; 1E2P A; 4JBY A; 2FG7 X; 1E2J A; 1KI2 A; 1P72 A; 1E2K A; 3KZO A; 1P7C A; 2KI5 A; 3L06 A; 1E2M A; 1KI7 A; 4IVQ A; 1KIM A; 1P6X A; 3VTK A; 1OSN A; 1P73 A; 3KZN A; #chains in the KnotProt database with same CATH homology 3RDP A; 1E2N A; 1KI6 A; 4IVP A; 1VTK A; 1KI6 B; 3F0T A; 1E2H A; 1KI4 A; 1QHI A; 1OF1 A; 4JBX A; 1E2I A; 1KI3 A; 1P75 A; 2VTK A; 1F48 A; 1E2L A; 1KI8 A; 4IVR A; 1E2P A; 4JBY A; 1E2J A; 1KI2 A; 1P72 A; 1E2K A; 1P7C A; 2KI5 A; 1E2M A; 1KI7 A; 4IVQ A; 1KIM A; 1P6X A; 1OSN A; 1P73 A; 3VTK A;
#similar chains in the KnotProt database (40% sequence similarity)
1E2K A; 4IVQ A; 1OF1 A; 4JBY A; 1E2H A; 1E2I A; 4JBX A; 1QHI A; 4IVP A; 4OQL A; 3F0T A; 2KI5 A; 4OQM A; 1KI2 A; 1KIM A; 1KI8 A; 1KI7 A; 1E2N A; 4OQN A; 1E2M A; 1P7C A; 1KI3 A; 4IVR A; 1KI4 A; 4OQX A; 1E2L A; 1KI6 A; 1KI6 B; 1E2P A; 1E2J A; 2VTK A; 1VTK A; 3RDP A; 3VTK A;
#similar chains in the pdb database (40% sequence similarity)
1E2K B; 4IVQ B; 1OF1 B; 4JBY B; 1E2H B; 1E2I B; 4JBX B; 1QHI B; 4IVP B; 4OQL B; 3F0T B; 2KI5 B; 4OQM B; 1KI2 B; 1KIM B; 1KI8 B; 1KI7 B; 1E2N B; 4OQN B; 1E2M B; 1P7C B; 1KI3 B; 4IVR B; 1KI4 B; 4OQX B; 1E2L B; 1E2P B; 1E2J B; 3RDP B;