S +31
|
S 3x +31
|
|
1t9nA
|
Effect of shuttle location and ph environment on h+ transfer in human carbonic anhydrase ii
|
K +31
|
K 3x +31
|
|
6fe1A
|
Three dimensional structure of human carbonic anhydrase ix in complex with benzenesulfonamide.
|
S +31
|
S 15x +31
|
|
4q8yA
|
Crystal structure of 2-hydroxyisoquinoline-1(2h)-thione bound to human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
5o07A
|
The crystal structure of the human carbonic anhydrase ii in complex with a nitroimidazole sulfamate inhibitor
|
S +31
|
S 3x +31
|
|
5n1sA
|
Crystal structure of human carbonic anhydrase ii in complex with the inhibitor 4-(1h-indol-2-yl)-benzenesulfonamide
|
S +31
|
S 3x +31
|
|
5e2rA
|
The crystal structure of the human carbonic anhydrase ii in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor
|
K +31
|
K 3x +31
|
|
3ryxB
|
Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the hydrophobic wall of carbonic anhydrase
|
S +31
|
S 11x +31
|
|
4yxuA
|
Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (4).
|
S +31
|
S 3x +31
|
|
4rh2A
|
Crystal structure of human carbonic anhydrase ii in complex with 2-(6-hydroxy-3-oxo-3h-xanthen-9-yl)-5-{3-1-(4-sulfamoyl-phenyl)-1h-[1,2,3]triazol-4-ylmethyl-thioureido}-benzoic acid
|
S +31
|
S 11x +31
|
|
1bnwA
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 3x +31
|
|
1xq0A
|
Structure of human carbonic anhydrase ii with 4-[(3-bromo-4-o-sulfamoylbenzyl)(4-cyanophenyl)amino]-4h-[1,2,4]-triazole
|
K +31
|
K 3x +31
|
|
2fnmA
|
Activation of human carbonic anhdyrase ii by exogenous proton donors
|
S +31
|
S 3x +31
|
|
1fqrA
|
X-ray crystal structure of cobalt-bound f93i/f95m/w97v carbonic anhydrase (caii) variant
|
S +31
|
S 3x +31
|
|
5a25A
|
Rational engineering of a mesophilic carbonic anhydrase to an extreme halotolerant biocatalyst
|
S +31
|
S 3x +31
|
|
3k7kA
|
Crystal structure of the complex between carbonic anhydrase ii and anions
|
S +31
|
S 4x +31
|
|
6g4tA
|
The crystal structure of uninhibited c183s/c217s mutant of human ca vii
|
K +31
|
K 3x +31
|
|
3r16A
|
Human caii bound to n-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide
|
S +31
|
S 3x +31
|
|
1fr4A
|
X-ray crystal structure of copper-bound f93i/f95m/w97v carbonic anhydrase (caii) variant
|
S +31
|
S 3x +31
|
|
3v3iB
|
Kinetic and structural studies of thermostabilized mutants of hca ii.
|
S +31
|
S 11x +31
|
|
1oknA
|
Carbonic anhydrase ii complex with the 1okn inhibitor 4-sulfonamide-[1-(4-n-(5-fluorescein thiourea)butane)]
|
S +31
|
S 15x +31
|
|
4q7wA
|
Crystal structure of 1-hydroxy-6-methylpyridine-2(1h)-thione bound to human carbonic anhydrase ii
|
K +31
|
K 3x +31
|
|
5jehB
|
Human carbonic anhydrase ii (l198a) complexed with benzo[d]thiazole-2-sulfonamide
|
S +31
|
S 3x +31
|
|
5amgA
|
Three dimensional structure of human carbonic anhydrase ii in complex with 2-(pentylsulfamoyl)-4-sulfamoylbenzoic acid
|
K +31
|
K 3x +31
|
|
4q90A
|
Crystal structure of 4-methylpyridine-2(1h)-thione bound to human carbonic anhydrase ii
|
K +31
|
K 3x +31
|
4
|
2nnsA
|
Structure of inhibitor binding to carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
5e2kA
|
Crystal structure of human carbonic anhydrase ii in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor
|
K +31
|
K 3x +31
|
|
3myqA
|
Crystal structure of human carbonic anhydrase isozyme ii with 2-chloro-5-[(1h-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide
|
S +31
|
S 3x +31
|
|
4n16A
|
Structure of cholate bound to human carbonic anhydrase ii
|
K +31
|
K 3x +31
|
|
3m1qA
|
Carbonic anhydrase ii mutant w5c-h64c with opened disulfide bond
|
K +31
|
K 1x +31
|
|
2eu2A
|
Human carbonic anhydrase ii in complex with novel inhibitors
|
K +31
|
K 3x +31
|
|
2wejA
|
Thermodynamic optimisation of carbonic anhydrase fragment inhibitors
|
S +31
|
S 3x +31
|
|
3k2fA
|
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma
|
S +31
|
S 3x +31
|
|
3kigA
|
Mutant carbonic anhydrase ii in complex with an azide and an alkyne
|
S +31
|
S 3x +31
|
|
3d9zA
|
Use of carbonic anhydrase ii, ix active-site mimic, for the purpose of screening inhibitors for possible anti-cancer properties
|
S +31
|
S 3x +31
|
|
2q38A
|
Carbonic anhydrase ii in complex with saccharin at 1.95 angstrom
|
S +31
|
S 3x +31
|
|
2osmA
|
Inhibition of carbonic anhydrase ii by thioxolone: a mechanistic and structural study
|
S +31
|
S 3x +31
|
|
2nmxA
|
Structure of inhibitor binding to carbonic anhydrase i
|
K +31
|
K 2x +31
|
|
2x7tA
|
Structures of human carbonic anhydrase ii inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.
|
S +31
|
S 3x +31
|
|
3rldA
|
Crystal structure of the y7i mutant of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
6g9uA
|
Three dimensional structure of human carbonic anhydrase ix in complex with sulfonamide
|
K +31
|
K 3x +31
|
|
2iliA
|
Refine atomic structure of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
5wgpA
|
Human carbonic anhydrase ix-mimic complexed with acek
|
S +31
|
S 3x +31
|
|
5fl4A
|
Three dimensional structure of human carbonic anhydrase ix in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide
|
S +31
|
S 7x +31
|
|
5eoiA
|
Crystal structure of copper bound human carbonic anhydrase ii
|
S +31
|
S 7x +31
|
|
4q7sA
|
Crystal structure of 1-hydroxy-4-methylpyridine-2(1h)-thione bound to human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3tvoX
|
Human carbonic anhydrase ii proton transfer double mutant
|
K +31
|
K 3x +31
|
|
4fikA
|
Human carbonic anhydrase ii h64a complexed with thioxolone hydrolysis products
|
S +31
|
S 3x +31
|
|
4hf3A
|
Activity enhancers of h64a variant of human carbonic anhydrase ii possess multiple binding sites within and around the enzyme structure
|
S +31
|
S 3x +31
|
|
3lxeA
|
Human carbonic anhydrase i in complex with topiramate
|
S +31
|
S 3x +31
|
|
3u7cA
|
Crystal structure of the v143i mutant of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3u45X
|
Human carbonic anhydrase ii v143a
|
K +31
|
K 3x +31
|
|
3p55A
|
Human carbonic anhydrase ii in complex with p-(4-ferrocenyl-1h-1,2,3-triazol-1-yl)benzenesulfonamide
|
S +31
|
S 3x +31
|
|
1xpzA
|
Structure of human carbonic anhydrase ii with 4-[4-o-sulfamoylbenzyl)(4-cyanophenyl)amino]-4h-[1,2,4]-triazole
|
S +31
|
S 3x +31
|
|
3hktA
|
Human carbonic anhydrase ii in complex with alpha-d-glucopyranosyl-(1->4)-1-thio-beta-d-glucopyranosylsulfonamide
|
S +31
|
S 3x +31
|
|
3l14A
|
Human carbonic anhydrase ii complexed with althiazide
|
S +31
|
S 3x +31
|
|
3oilA
|
Human carbonic anhydrase ii mutant a65s, n67q (ca ix mimic) bound by 2-ethylestradiol 3-o-sulfamate
|
K +31
|
K 3x +31
|
|
2nwzA
|
Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3dvcA
|
X-ray crystal structure of mutant n62t of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1lg6A
|
Crystal structure analysis of hca ii mutant t199p in complex with thiocyanate
|
S +31
|
S 3x +31
|
|
3v3gB
|
Kinetic and structural studies of thermostabilized mutants of hca ii.
|
K +31
|
K 3x +31
|
|
3uynA
|
Hca 3
|
S +31
|
S 3x +31
|
|
3hfpA
|
Crystal structure of teh complex between ca ii and the activator mai
|
S +31
|
S 15x +31
|
|
4q8xA
|
Crystal structure of 1-hydroxy-5-(trifluoromethyl)pyridine-2(1h)-thione bound to human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
2nn1A
|
Structure of inhibitor binding to carbonic anhydrase i
|
S +31
|
S 11x +31
|
|
1a42A
|
Human carbonic anhydrase ii complexed with brinzolamide
|
K +31
|
K 1x +31
|
|
2hfxA
|
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase iii
|
S +31
|
S 3x +31
|
|
5dsmA
|
Structure of co2 released holo-form of human carbonic anhydrase ii with 25 min warming
|
S +31
|
S 3x +31
|
|
5dslA
|
Structure of co2 released holo-form of human carbonic anhydrase ii with 10 min warming
|
K +31
|
K 3x +31
|
|
4k1qA
|
Structure of hcaix mimic (hcaii with 5 mutations in active site)
|
K +31
|
K 3x +31
|
|
5ty8A
|
Identification of a new zinc binding chemotype by fragment screening
|
K +31
|
K 3x +31
|
|
5g0cA
|
An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of psammaplin c
|
S +31
|
S 3x +31
|
|
3s77B
|
The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase
|
K +31
|
K 3x +31
|
|
1fsrA
|
X-ray crystal structure of copper-bound f93s/f95l/w97m carbonic anhydrase (caii) variant
|
K +31
|
K 3x +31
|
|
6g98A
|
Three dimensional structure of human carbonic anhydrase ix in complex with sulfonamide
|
S +31
|
S 3x +31
|
|
5yuiA
|
Co2 release in human carbonic anhydrase ii crystals: reveal histidine 64 and solvent dynamics
|
K +31
|
K 3x +31
|
|
5dvxA
|
Crystal structure of the catalytic-domain of human carbonic anhydrase ix at 1.6 angstrom resolution
|
K +31
|
K 3x +31
|
|
5amdA
|
Three dimensional structure of human carbonic anhydrase ii in complex with 2-((2-phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid
|
K +31
|
K 3x +31
|
|
4hewA
|
Activity enhancers of h64a variant of human carbonic anhydrase ii possess multiple binding sites within and around the enzyme structure
|
K +31
|
K 3x +31
|
|
3okuA
|
Human carbonic anhydrase ii in complex with 2-ethylestrone-3-o-sulfamate
|
K +31
|
K 3x +31
|
|
1z93A
|
Human carbonic anhydrase iii:structural and kinetic study of catalysis and proton transfer.
|
S +31
|
S 3x +31
|
|
5n0eA
|
Crystal structure of human carbonic anhydrase ii in complex with (s)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1h-2-carbonyl)benzenesulfonamide.
|
S +31
|
S 3x +31
|
|
5llhA
|
Crystal structure of human carbonic anhydrase isozyme ii with 4-(1,3-benzothiazol-2-ylthio)-2,3,5,6-tetrafluorobenzenesulfonamide
|
S +31
|
S 7x +31
|
|
5fnkA
|
Native state mass spectrometry, surface plasmon resonance and x-ray crystallography correlate strongly as a fragment screening combination
|
S +31
|
S 3x +31
|
|
3m1wA
|
Carbonic anhyrdase ii mutant w5ch64c with closed disulfide bond in complex with sulfate
|
S +31
|
S 3x +31
|
|
5fngA
|
Native state mass spectrometry, surface plasmon resonance and x-ray crystallography correlate strongly as a fragment screening combination
|
S +31
|
S 3x +31
|
|
3uyqA
|
Hca 3
|
S +31
|
S 23x +31
|
|
1bnvA
|
Carbonic anhydrase ii inhibitor
|
S +31
|
S 3x +31
|
|
3m5sA
|
Carbonic anhydrase ii mutant h64c in complex with carbonate
|
S +31
|
S 3x +31
|
|
2weoA
|
Thermodynamic optimisation of carbonic anhydrase fragment inhibitors
|
S +31
|
S 3x +31
|
|
2nn7A
|
Structure of inhibitor binding to carbonic anhydrase i
|
S +31
|
S 3x +31
|
|
5ogoA
|
Crystal structure of chimeric carbonic anhydrase i with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
|
S +31
|
S 3x +31
|
|
4xfwA
|
Crystal structure of the monoclinic form of alpha-carbonic anhydrase from the human pathogen helicobacter pylori
|
S +31
|
S 3x +31
|
|
4xiwA
|
Carbonic anhydrase cah3 from chlamydomonas reinhardtii in complex with acetazolamide
|
S +31
|
S 3x +31
|
|
4cq0A
|
Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes
|
S +31
|
S 3x +31
|
|
4cnxA
|
Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion co2 capture
|
S +31
|
S 15x +31
|
|
3kwaA
|
Polyamines inhibit carbonic anhydrases
|
S +31
|
S 3x +31
|
|
3dccA
|
Use of carbonic anhydrase ii, ix active-site mimic, for the purpose of screening inhibitors for possible anti-cancer properties
|
S +31
|
S 7x +31
|
|
1i9qA
|
Carbonic anhydrase ii (f131v) complexed with 4-(aminosulfonyl)-n-[(3,4,5-trifluorophenyl)methyl]-benzamide
|
S +31
|
S 15x +31
|
|
1i9lA
|
Carbonic anhydrase ii (f131v) complexed with 4-(aminosulfonyl)-n-[(4-fluorophenyl)methyl]-benzamide
|
S +31
|
S 11x +31
|
|
2hkkA
|
Carbonic anhydrase activators: solution and x-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms
|
S +31
|
S 3x +31
|
|
1fljA
|
Crystal structure of s-glutathiolated carbonic anhydrase iii
|
S +31
|
S 3x +31
|
|
2aw1A
|
Carbonic anhydrase inhibitors: valdecoxib binds to a different active site region of the human isoform ii as compared to the structurally related cyclooxygenase ii "selective" inhibitor celecoxib
|
S +31
|
S 3x +31
|
|
1fr7A
|
X-ray crystal structure of zinc-bound f93s/f95l/w97m carbonic anhydrase (caii) variant
|
S +31
|
S 11x +31
|
|
2hl4A
|
Crystal structure analysis of human carbonic anhydrase ii in complex with a benzenesulfonamide derivative
|
S +31
|
S 3x +31
|
|
5wg7A
|
Human carbonic anhydrase ii complexed with acek
|
S +31
|
S 3x +31
|
|
5mjnA
|
Three dimensional structure of human carbonic anhydrase ii in complex with 5-[(4chlorobenzyl)sulfanyl]thiophene-2-sulfonamide
|
S +31
|
S 3x +31
|
|
5jg3B
|
Human carbonic anhydrase ii (121t/n67q) complexed with benzo[d]thiazole-2-sulfonamide
|
K +31
|
K 3x +31
|
|
5je7B
|
Human carbonic anhydrase ii (f131y) complexed with benzo[d]thiazole-2-sulfonamide
|
S +31
|
S 3x +31
|
|
5jegB
|
Human carbonic anhydrase ii (v121i) complexed with benzo[d]thiazole-2-sulfonamide
|
S +31
|
S 3x +31
|
|
5j8zA
|
Human carbonic anhydrase ii in complex with ligand
|
S +31
|
S 3x +31
|
|
4y0jA
|
H/d exchanged human carbonic anhydrase ii ph 6 room temperature neutron crystal structure.
|
K +31
|
K 3x +31
|
|
4z1jA
|
Carbonic anhydrase inhibitors: design and synthesis of new heteroaryl-n-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hca vii, hca ix, and hca xiv)
|
S +31
|
S 7x +31
|
|
5byiA
|
Human carbonic anhydrase ii with an azobenzene inhibitor (1d)
|
S +31
|
S 3x +31
|
|
5c8iA
|
Joint x-ray/neutron structure of human carbonic anhydrase ii in complex with methazolamide
|
S +31
|
S 3x +31
|
|
4rfdA
|
Human carbonic anhydrase ii in complex with 4-(4-sulfamoyl-phenoxy)-butylammonium
|
S +31
|
S 3x +31
|
|
4l5wA
|
Structural implications of the secondary co2 binding pocket in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3tvnX
|
Human carbonic anhydrase ii proton transfer mutant
|
S +31
|
S 3x +31
|
|
4hezA
|
Activity enhancers of h64a variant of human carbonic anhydrase ii possess multiple binding sites within and around the enzyme structure
|
S +31
|
S 3x +31
|
|
3rg3A
|
Crystal structure of the w5e mutant of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3oimA
|
Human carbonic anhydrase ii bound by 2-ethylestradiol 3-o-sulfamate
|
S +31
|
S 3x +31
|
|
3rg4A
|
Crystal structure of the w5f mutant of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3rgeA
|
Crystal structure of the w5h mutant of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
3p3hA
|
Human carbonic anhydrase ii in complex with p-(5-ferrocenyl-1h-1,2,3-triazol-1-yl)benzenesulfonamide
|
S +31
|
S 3x +31
|
|
2nxrA
|
Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase ii
|
K +31
|
K 3x +31
|
|
3dvbA
|
X-ray crystal structure of mutant n62v human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1tg3A
|
Effect of shuttle location and ph environment on h+ transfer in human carbonic anhydrase ii
|
K +31
|
K 3x +31
|
|
2powA
|
The crystal structure of the human carbonic anhydrase ii in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
|
S +31
|
S 3x +31
|
|
2nxsA
|
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1yo1A
|
Proton transfer from his200 in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1teuX
|
Effect of shuttle location and ph environment on h+ transfer in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1tg9A
|
Effect of shuttle location and ph environment on h+ transfer in human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1lzvA
|
Site-specific mutant (tyr7 replaced with his) of human carbonic anhydrase ii
|
S +31
|
S 3x +31
|
|
1kwrA
|
Human carbonic anhydrase ii complexed with inhibitor 0134-36
|
S +31
|
S 3x +31
|
|
6b4dA
|
Crystal structure of human carbonic anhydrase ii in complex with a heteroaryl-pyrazole carboxylic acid derivative.
|
S +31
|
S 3x +31
|
|
5n0dA
|
Crystal structure of human carbonic anhydrase ii in complex with (r)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1h-2-carbonyl)benzenesulfonamide.
|
S +31
|
S 15x +31
|
|
5jqtA
|
Crystal structure of human carbonic anhydrase ii in complex with benzoxaborole at ph 7.4
|
S +31
|
S 3x +31
|
|
5zxwA
|
Crystal structure of human carbonic anhydrase ii crystallized by ammonium sulfate
|
S +31
|
S 3x +31
|
|
5llaA
|
Crystal structure of human carbonic anhydrase isozyme xiii with 4-(1h-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
|
S +31
|
S 3x +31
|
|
5ll5A
|
Crystal structure of human carbonic anhydrase isozyme xii with 4-(1h-benzimidazol-1-ylacetyl)benzenesulfonamide
|
S +31
|
S 3x +31
|
|
5gmmA
|
Crystal structure of human carbonic anhydrase i in complex with polmacoxib
|
S +31
|
S 3x +31
|
|
5e28A
|
Crystal structure of human carbonic anhydrase ii in complex with the 4-(4-aminophenyl)benzenesulfonamide inhibitor
|
S +31
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S 3x +31
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4yvyA
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Crystal structure of human carbonic anhydrase ii in complex with hydroxylamine-o-sulfonamide, a molecule incorporating two zinc-binding groups.
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K +31
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1urtA
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Murine carbonic anhydrase v
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S +31
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S 3x +31
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3mdzA
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Crystal structure of human carbonic anhydrase vii [isoform 1], ca7
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S +31
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S 3x +31
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1xegA
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Crystal structure of human carbonic anhydrase ii complexed with an acetate ion
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S +31
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S 23x +31
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2gehA
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N-hydroxyurea, a versatile zinc binding function in the design of metalloenzyme inhibitors
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S +31
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S 7x +31
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1ugeA
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Human carbonic anhydrase ii [hcaii] (e.c.4.2.1.1) mutant with ala 65 replaced by leu (a65l)
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S +31
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S 11x +31
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1bnmA
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Carbonic anhydrase ii inhibitor
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S +31
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S 11x +31
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2h15A
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Carbonic anhydrase inhibitors: clashing with ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme ii
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S +31
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S 11x +31
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4yxoA
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Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (3).
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