2AGXD

Crystal structure of the schiff base intermediate in the reductive half-reaction of aromatic amine dehydrogenase (aadh) with tryptamine. p212121 form
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 17-74 58 1-16, 75-82 16 8 knot
Fingerprint Knot forming loop Loop type
K +31 Glu71 ... Cys75 <-> Cys140 ... Cys113 <-> Cys81 ... Trq109 <-> Trp160 ...
Chain closureLeu179 <-> Glu71
probabilistic
Chain Sequence
EVNSCDYWRHCAVDGFLCSCCGGTTTTCPPGSTPSPIS-IGTCHNPHDGKDYLISYHDCCGKTACGRCQCNTQTRERPGYEFFLHNDVNWCMANENSTFHCTTSVLVGL
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
sequence length 109
structure length 108
publication title Atomic description of an enzyme reaction dominated by proton tunneling
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Aromatic amine dehydrogenase
missing residues 39
total genus Genus: 27
ec nomenclature ec 1.4.9.2: Aralkylamine dehydrogenase (azurin).
pdb deposition date 2005-07-27
KnotProt deposition date 2018-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF02975 Me-amine-dh_L Methylamine dehydrogenase, L chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.30.10 Mainly Beta Sandwich Electron Transport Ethylamine Dehydrogenase Electron Transport Ethylamine Dehydrogenase 2agxD00
2.60.30.10 Mainly Beta Sandwich Electron Transport Ethylamine Dehydrogenase Electron Transport Ethylamine Dehydrogenase 2agxD00
2GC4B 2HJBD 2H47B 1MDAM 2AGWD 2J55L 2AH0D 2J57K 3L4OC 2AH1D 2HXCD 1MG3B 2HKRD 2J56L 2AGXD 2IURD 2OIZD 2AGYD 2OK4D 3C75L 2I0TD 2I0SD 2H3XB 2MTAL 2IAAB 2AGLD 2OJYD 2HJ4D 2IUQD 2GC7B 2HKMD 2Q7QD 1MG2B 2IUPD 2MADL 2BBKL 2IUVD
chains in the KnotProt database with same CATH superfamily
2GC4B 2HJBD 2H47B 1MDAM 2AGWD 2J55L 2AH0D 2J57K 3L4OC 2AH1D 2HXCD 1MG3B 2HKRD 2J56L 2AGXD 2IURD 2OIZD 2AGYD 2OK4D 3C75L 2I0TD 2I0SD 2H3XB 2MTAL 2IAAB 2AGLD 2OJYD 2HJ4D 2IUQD 2GC7B 2HKMD 2Q7QD 1MG2B 2IUPD 2MADL 2BBKL 2IUVD
chains in the KnotProt database with same CATH topology
2GC4B 2HJBD 2H47B 1MDAM 2AGWD 2J55L 2AH0D 2J57K 3L4OC 2AH1D 2HXCD 1MG3B 2HKRD 2J56L 2AGXD 2IURD 2OIZD 2AGYD 2OK4D 3C75L 2I0TD 2I0SD 2H3XB 2MTAL 2IAAB 2AGLD 2OJYD 2HJ4D 2IUQD 2GC7B 2HKMD 2Q7QD 1MG2B 2IUPD 2MADL 2BBKL 2IUVD
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 2GC4 B;  2HJB D;  2H47 B;  1MDA M;  2AGW D;  2J55 L;  2AH0 D;  2J57 K;  3L4O C;  2AH1 D;  2HXC D;  1MG3 B;  2HKR D;  2J56 L;  2AGX D;  2IUR D;  2OIZ D;  2AGY D;  2OK4 D;  3C75 L;  2I0T D;  2I0S D;  2H3X B;  2MTA L;  2IAA B;  2AGL D;  2OJY D;  2HJ4 D;  2IUQ D;  2GC7 B;  2HKM D;  2Q7Q D;  1MG2 B;  2IUP D;  2MAD L;  2BBK L;  2IUV D; 
#chains in the KnotProt database with same CATH topology
 2GC4 B;  2HJB D;  2H47 B;  1MDA M;  2AGW D;  2J55 L;  2AH0 D;  2J57 K;  3L4O C;  2AH1 D;  2HXC D;  1MG3 B;  2HKR D;  2J56 L;  2AGX D;  2IUR D;  2OIZ D;  2AGY D;  2OK4 D;  3C75 L;  2I0T D;  2I0S D;  2H3X B;  2MTA L;  2IAA B;  2AGL D;  2OJY D;  2HJ4 D;  2IUQ D;  2GC7 B;  2HKM D;  2Q7Q D;  1MG2 B;  2IUP D;  2MAD L;  2BBK L;  2IUV D; 
#chains in the KnotProt database with same CATH homology
 2GC4 B;  2HJB D;  2H47 B;  1MDA M;  2AGW D;  2J55 L;  2AH0 D;  2J57 K;  3L4O C;  2AH1 D;  2HXC D;  1MG3 B;  2HKR D;  2J56 L;  2AGX D;  2IUR D;  2OIZ D;  2AGY D;  2OK4 D;  3C75 L;  2I0T D;  2I0S D;  2H3X B;  2MTA L;  2IAA B;  2AGL D;  2OJY D;  2HJ4 D;  2IUQ D;  2GC7 B;  2HKM D;  2Q7Q D;  1MG2 B;  2IUP D;  2MAD L;  2BBK L;  2IUV D; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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