2HKRD

Structures of the carbinolamine and schiff-base intermediates in the reductive half-reaction of aromatic amine dehydrogenase (aadh) with p-methoxyphenylethylamine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 16-75 60 1-15, 76-83 15 8 knot
Fingerprint Knot forming loop Loop type
K +31 Glu71 ... Cys75 <-> Cys140 ... Cys113 <-> Cys81 ... Trq109 <-> Trp160 ...
Chain closureAla180 <-> Glu71
 probabilistic
Chain Sequence
EVNSCDYWRHCAVDGFLCSCCGGTTTTCPPGSTPSPIS-IGTCHNPHDGKDYLISYHDCCGKTACGRCQCNTQTRERPGYEFFLHNDVNWCMANENSTFHCTTSVLVGLA
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
sequence length 110
structure length 109
publication title Structure-reactivity correlations and kinetic isotope effects in aromatic amine dehydrogenase
rcsb
molecule tags Oxidoreductase
molecule keywords Aromatic amine dehydrogenase, small subunit
source organism Alcaligenes faecalis
missing residues 39
total genus Genus: 27
ec nomenclature ec 1.4.9.2: Aralkylamine dehydrogenase (azurin).
pdb deposition date 2006-07-05
KnotProt deposition date 2018-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF02975 Me-amine-dh_L Methylamine dehydrogenase, L chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.30.10 Mainly Beta Sandwich Electron Transport Ethylamine Dehydrogenase Electron Transport Ethylamine Dehydrogenase 2hkrD00
2.60.30.10 Mainly Beta Sandwich Electron Transport Ethylamine Dehydrogenase Electron Transport Ethylamine Dehydrogenase 2hkrD00
2IUPD 2I0SD 2HJ4D 2HXCD 3L4OC 2I0TD 2HKRD 1MG2B 2OIZD 2OJYD 2BBKL 2AH0D 2AH1D 1MDAM 2Q7QD 2IURD 2GC4B 2AGYD 2IUVD 1MG3B 2HJBD 3C75L 2IAAB 2OK4D 2J57K 2AGLD 2J55L 2H47B 2GC7B 2AGWD 2MADL 2AGXD 2HKMD 2H3XB 2J56L 2IUQD 2MTAL
chains in the KnotProt database with same CATH superfamily
2IUPD 2I0SD 2HJ4D 2HXCD 3L4OC 2I0TD 2HKRD 1MG2B 2OIZD 2OJYD 2BBKL 2AH0D 2AH1D 1MDAM 2Q7QD 2IURD 2GC4B 2AGYD 2IUVD 1MG3B 2HJBD 3C75L 2IAAB 2OK4D 2J57K 2AGLD 2J55L 2H47B 2GC7B 2AGWD 2MADL 2AGXD 2HKMD 2H3XB 2J56L 2IUQD 2MTAL
chains in the KnotProt database with same CATH topology
2IUPD 2I0SD 2HJ4D 2HXCD 3L4OC 2I0TD 2HKRD 1MG2B 2OIZD 2OJYD 2BBKL 2AH0D 2AH1D 1MDAM 2Q7QD 2IURD 2GC4B 2AGYD 2IUVD 1MG3B 2HJBD 3C75L 2IAAB 2OK4D 2J57K 2AGLD 2J55L 2H47B 2GC7B 2AGWD 2MADL 2AGXD 2HKMD 2H3XB 2J56L 2IUQD 2MTAL
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2IUP D;  2I0S D;  2HJ4 D;  2HXC D;  3L4O C;  2I0T D;  2HKR D;  1MG2 B;  2OIZ D;  2OJY D;  2BBK L;  2AH0 D;  2AH1 D;  1MDA M;  2Q7Q D;  2IUR D;  2GC4 B;  2AGY D;  2IUV D;  1MG3 B;  2HJB D;  3C75 L;  2IAA B;  2OK4 D;  2J57 K;  2AGL D;  2J55 L;  2H47 B;  2GC7 B;  2AGW D;  2MAD L;  2AGX D;  2HKM D;  2H3X B;  2J56 L;  2IUQ D;  2MTA L; 
#chains in the KnotProt database with same CATH topology
 2IUP D;  2I0S D;  2HJ4 D;  2HXC D;  3L4O C;  2I0T D;  2HKR D;  1MG2 B;  2OIZ D;  2OJY D;  2BBK L;  2AH0 D;  2AH1 D;  1MDA M;  2Q7Q D;  2IUR D;  2GC4 B;  2AGY D;  2IUV D;  1MG3 B;  2HJB D;  3C75 L;  2IAA B;  2OK4 D;  2J57 K;  2AGL D;  2J55 L;  2H47 B;  2GC7 B;  2AGW D;  2MAD L;  2AGX D;  2HKM D;  2H3X B;  2J56 L;  2IUQ D;  2MTA L; 
#chains in the KnotProt database with same CATH homology
 2IUP D;  2I0S D;  2HJ4 D;  2HXC D;  3L4O C;  2I0T D;  2HKR D;  1MG2 B;  2OIZ D;  2OJY D;  2BBK L;  2AH0 D;  2AH1 D;  1MDA M;  2Q7Q D;  2IUR D;  2GC4 B;  2AGY D;  2IUV D;  1MG3 B;  2HJB D;  3C75 L;  2IAA B;  2OK4 D;  2J57 K;  2AGL D;  2J55 L;  2H47 B;  2GC7 B;  2AGW D;  2MAD L;  2AGX D;  2HKM D;  2H3X B;  2J56 L;  2IUQ D;  2MTA L;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling