2HKMD

Crystal structure of the schiff base intermediate in the reductive half-reaction of aromatic amine dehydrogenase (aadh) with phenylethylamine.
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 17-74 58 1-16, 75-83 16 9 knot
Fingerprint Knot forming loop Loop type
K +31 Glu71 ... Cys75 <-> Cys140 ... Cys113 <-> Cys81 ... Trq109 <-> Trp160 ...
Chain closureAla180 <-> Glu71
 probabilistic
Chain Sequence
EVNSCDYWRHCAVDGFLCSCCGGTTTTCPPGSTPSPIS-IGTCHNPHDGKDYLISYHDCCGKTACGRCQCNTQTRERPGYEFFLHNDVNWCMANENSTFHCTTSVLVGLA
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
sequence length 110
structure length 109
publication title Structure-reactivity correlations and kinetic isotope effects in aromatic amine dehydrogenase
rcsb
molecule tags Oxidoreductase
molecule keywords Aromatic amine dehydrogenase
missing residues 39
total genus Genus: 27
ec nomenclature ec 1.4.9.2: Aralkylamine dehydrogenase (azurin).
pdb deposition date 2006-07-05
KnotProt deposition date 2018-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF02975 Me-amine-dh_L Methylamine dehydrogenase, L chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.30.10 Mainly Beta Sandwich Electron Transport Ethylamine Dehydrogenase Electron Transport Ethylamine Dehydrogenase 2hkmD00
2.60.30.10 Mainly Beta Sandwich Electron Transport Ethylamine Dehydrogenase Electron Transport Ethylamine Dehydrogenase 2hkmD00
2HKMD 2HKRD 2IUQD 2OIZD 3C75L 2AGLD 2IUVD 2MTAL 2BBKL 1MDAM 2AGXD 2OJYD 2HJBD 2IUPD 2GC4B 2J57K 2GC7B 1MG3B 2AH0D 2AGWD 2HXCD 2H47B 2AH1D 2I0SD 2IAAB 2Q7QD 2J56L 2MADL 2HJ4D 2AGYD 2OK4D 2J55L 1MG2B 2I0TD 2H3XB 2IURD 3L4OC
chains in the KnotProt database with same CATH superfamily
2HKMD 2HKRD 2IUQD 2OIZD 3C75L 2AGLD 2IUVD 2MTAL 2BBKL 1MDAM 2AGXD 2OJYD 2HJBD 2IUPD 2GC4B 2J57K 2GC7B 1MG3B 2AH0D 2AGWD 2HXCD 2H47B 2AH1D 2I0SD 2IAAB 2Q7QD 2J56L 2MADL 2HJ4D 2AGYD 2OK4D 2J55L 1MG2B 2I0TD 2H3XB 2IURD 3L4OC
chains in the KnotProt database with same CATH topology
2HKMD 2HKRD 2IUQD 2OIZD 3C75L 2AGLD 2IUVD 2MTAL 2BBKL 1MDAM 2AGXD 2OJYD 2HJBD 2IUPD 2GC4B 2J57K 2GC7B 1MG3B 2AH0D 2AGWD 2HXCD 2H47B 2AH1D 2I0SD 2IAAB 2Q7QD 2J56L 2MADL 2HJ4D 2AGYD 2OK4D 2J55L 1MG2B 2I0TD 2H3XB 2IURD 3L4OC
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2HKM D;  2HKR D;  2IUQ D;  2OIZ D;  3C75 L;  2AGL D;  2IUV D;  2MTA L;  2BBK L;  1MDA M;  2AGX D;  2OJY D;  2HJB D;  2IUP D;  2GC4 B;  2J57 K;  2GC7 B;  1MG3 B;  2AH0 D;  2AGW D;  2HXC D;  2H47 B;  2AH1 D;  2I0S D;  2IAA B;  2Q7Q D;  2J56 L;  2MAD L;  2HJ4 D;  2AGY D;  2OK4 D;  2J55 L;  1MG2 B;  2I0T D;  2H3X B;  2IUR D;  3L4O C; 
#chains in the KnotProt database with same CATH topology
 2HKM D;  2HKR D;  2IUQ D;  2OIZ D;  3C75 L;  2AGL D;  2IUV D;  2MTA L;  2BBK L;  1MDA M;  2AGX D;  2OJY D;  2HJB D;  2IUP D;  2GC4 B;  2J57 K;  2GC7 B;  1MG3 B;  2AH0 D;  2AGW D;  2HXC D;  2H47 B;  2AH1 D;  2I0S D;  2IAA B;  2Q7Q D;  2J56 L;  2MAD L;  2HJ4 D;  2AGY D;  2OK4 D;  2J55 L;  1MG2 B;  2I0T D;  2H3X B;  2IUR D;  3L4O C; 
#chains in the KnotProt database with same CATH homology
 2HKM D;  2HKR D;  2IUQ D;  2OIZ D;  3C75 L;  2AGL D;  2IUV D;  2MTA L;  2BBK L;  1MDA M;  2AGX D;  2OJY D;  2HJB D;  2IUP D;  2GC4 B;  2J57 K;  2GC7 B;  1MG3 B;  2AH0 D;  2AGW D;  2HXC D;  2H47 B;  2AH1 D;  2I0S D;  2IAA B;  2Q7Q D;  2J56 L;  2MAD L;  2HJ4 D;  2AGY D;  2OK4 D;  2J55 L;  1MG2 B;  2I0T D;  2H3X B;  2IUR D;  3L4O C;
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling