1E2MA

Hpt + hmtt
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 110
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 5-116 112 1-4 305-329 117-304 4 25 slipknot
Chain Sequence
MPTLLRVYIDGPHGMGKTTTTQLL-----RDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSPPALT----LIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRPHIGDTL---------------FTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-113 106 1-7 144-305 114-143 7 162 slipknot
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2.1 8-148 141 1-7 221-305 149-220 7 85 slipknot
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2.1 8-221 214 1-7 264-305 222-263 7 42 slipknot
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3.1 6-264 259 1-5 279-305 265-278 5 27 slipknot
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2.1 9-221 213 1-7, 263-305 8-8, 222-262 7 43 slipknot
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2.1 8-264 257 1-5, 278-305 6-7, 265-277 5 28 slipknot
sequence length 329
structure length 305
publication title The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
pubmed doi rcsb
molecule tags Transferase
molecule keywords THYMIDINE KINASE
source organism Herpes simplex virus (type 1 / strain 17)
missing residues 25-29, 105-108, 220-234
total genus Genus: 110
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2000-05-23
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1e2mA00
1E2KA 1P72A 1KIMA 4JBYA 1E2HA 1E2JA 3F0TA 1KI7A 2VTKA 1GKUB 1E2MA 1OSNA 1QHIA 1E2IA 3RDPA 1E2PA 1KI6B 1VTKA 4JBXA 1P6XA 1OF1A 1KI2A 4IVPA 1KI4A 1P73A 3VTKA 1P75A 1KI3A 1KI6A 4IVRA 2KI5A 1F48A 1KI8A 1E2NA 1P7CA 1II9A 4IVQA 1E2LA
chains in the KnotProt database with same CATH superfamily
1E2KA 2G7MC 1P72A 3KZCA 1KIMA 4JBYA 1E2HA 1E2JA 3F0TA 1KI7A 3L06A 3KZNA 1JS1X 1YH1A 3KZMA 2VTKA 1GKUB 1E2MA 1YVEI 1OSNA 1QHIA 1E2IA 3FR8A 3RDPA 1E2PA 1KI6B 1VTKA 4JBXA 1P6XA 1R4NB 2XTJA 3KZKA 1OF1A 1KI2A 4IVPA 3FSGA 3L04A 1KI4A 1P73A 3L02A 3L05A 1P75A 3VTKA 1KI3A 1KI6A 1YRLA 3M4JA 4IVRA 1R4MB 2KI5A 1F48A 1KI8A 1LNSA 1E2NA 2FG6C 3M5CA 1DBIA 1QMGA 1P7CA 3KZOA 1II9A 3M5DA 3M4NA 4IVQA 3FR7A 1E2LA
chains in the KnotProt database with same CATH topology
1E2KA 1P72A 1KIMA 4JBYA 1E2HA 1E2JA 3F0TA 1KI7A 2VTKA 1GKUB 1E2MA 1OSNA 1QHIA 1E2IA 3RDPA 1E2PA 1KI6B 1VTKA 4JBXA 1P6XA 1OF1A 1KI2A 4IVPA 1KI4A 1P73A 3VTKA 1P75A 1KI3A 1KI6A 4IVRA 2KI5A 1F48A 1KI8A 1E2NA 1P7CA 1II9A 4IVQA 1E2LA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1E2K A;  1P72 A;  1KIM A;  4JBY A;  1E2H A;  1E2J A;  3F0T A;  1KI7 A;  2VTK A;  1GKU B;  1E2M A;  1OSN A;  1QHI A;  1E2I A;  3RDP A;  1E2P A;  1KI6 B;  1VTK A;  4JBX A;  1P6X A;  1OF1 A;  1KI2 A;  4IVP A;  1KI4 A;  1P73 A;  3VTK A;  1P75 A;  1KI3 A;  1KI6 A;  4IVR A;  2KI5 A;  1F48 A;  1KI8 A;  1E2N A;  1P7C A;  1II9 A;  4IVQ A;  1E2L A; 
#chains in the KnotProt database with same CATH topology
 1E2K A;  2G7M C;  1P72 A;  3KZC A;  1KIM A;  4JBY A;  1E2H A;  1E2J A;  3F0T A;  1KI7 A;  3L06 A;  3KZN A;  1JS1 X;  1YH1 A;  3KZM A;  2VTK A;  1GKU B;  1E2M A;  1YVE I;  1OSN A;  1QHI A;  1E2I A;  3FR8 A;  3RDP A;  1E2P A;  1KI6 B;  1VTK A;  4JBX A;  1P6X A;  1R4N B;  2XTJ A;  3KZK A;  1OF1 A;  1KI2 A;  4IVP A;  3FSG A;  3L04 A;  1KI4 A;  1P73 A;  3L02 A;  3L05 A;  1P75 A;  3VTK A;  1KI3 A;  1KI6 A;  1YRL A;  3M4J A;  4IVR A;  1R4M B;  2KI5 A;  1F48 A;  1KI8 A;  1LNS A;  1E2N A;  2FG6 C;  3M5C A;  1DBI A;  1QMG A;  1P7C A;  3KZO A;  1II9 A;  3M5D A;  3M4N A;  4IVQ A;  3FR7 A;  1E2L A; 
#chains in the KnotProt database with same CATH homology
 1E2K A;  1P72 A;  1KIM A;  4JBY A;  1E2H A;  1E2J A;  3F0T A;  1KI7 A;  2VTK A;  1GKU B;  1E2M A;  1OSN A;  1QHI A;  1E2I A;  3RDP A;  1E2P A;  1KI6 B;  1VTK A;  4JBX A;  1P6X A;  1OF1 A;  1KI2 A;  4IVP A;  1KI4 A;  1P73 A;  3VTK A;  1P75 A;  1KI3 A;  1KI6 A;  4IVR A;  2KI5 A;  1F48 A;  1KI8 A;  1E2N A;  1P7C A;  1II9 A;  4IVQ A;  1E2L A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling