2XTJA

The crystal structure of pcsk9 in complex with 1d05 fab
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 83
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 29-99 71 1-28 102-268 100-101 28 167 slipknot
Chain Sequence
PWN--------------------SLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDQASKCDSHGTHLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLILFSAKD
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 10-69 60 1-9 78-242 70-77 9 165 slipknot
view details
1.1 15-70 56 1-9, 78-242 10-14, 71-77 9 165 slipknot
sequence length 268
structure length 242
publication title A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo.
pubmed doi rcsb
molecule tags Hydrolase/antibody
molecule keywords PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
source organism Homo sapiens
missing residues 4-23, 59-64
total genus Genus: 83
ec nomenclature ec 3.4.21.-:
pdb deposition date 2010-10-10
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00082 Peptidase_S8 Subtilase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.200 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Rossmann fold 2xtjA00
2XTJA 1DBIA
chains in the KnotProt database with same CATH superfamily
4JBXA 1KI3A 1OSNA 1LNSA 3KZNA 3FSGA 1P6XA 4IVQA 3RDPA 1F48A 1YVEI 3L02A 1YRLA 1JS1X 1DBIA 1II9A 3KZMA 1E2HA 1VTKA 2KI5A 3KZKA 3L06A 3M4JA 3VTKA 1E2NA 1E2PA 1E2KA 1KI6A 1E2MA 1YH1A 4JBYA 1OF1A 3M4NA 2XTJA 1P73A 1E2LA 3L04A 3M5DA 1R4NB 3M5CA 1P7CA 1QMGA 1P72A 2FG6C 3KZCA 4IVPA 1KIMA 1KI6B 1GKUB 1P75A 3L05A 3KZOA 1KI2A 1KI7A 1E2IA 1E2JA 1KI4A 2G7MC 1R4MB 1KI8A 1QHIA 3FR7A 3FR8A 3F0TA 4IVRA 2VTKA
chains in the KnotProt database with same CATH topology
3KZNA 1LNSA 3FSGA 3L02A 1JS1X 1DBIA 3KZMA 3KZKA 3L06A 3M4JA 1YH1A 3M4NA 2XTJA 3L04A 3M5DA 3M5CA 2FG6C 3KZCA 1GKUB 3L05A 3KZOA 2G7MC
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2XTJ A;  1DBI A; 
#chains in the KnotProt database with same CATH topology
 4JBX A;  1KI3 A;  1OSN A;  1LNS A;  3KZN A;  3FSG A;  1P6X A;  4IVQ A;  3RDP A;  1F48 A;  1YVE I;  3L02 A;  1YRL A;  1JS1 X;  1DBI A;  1II9 A;  3KZM A;  1E2H A;  1VTK A;  2KI5 A;  3KZK A;  3L06 A;  3M4J A;  3VTK A;  1E2N A;  1E2P A;  1E2K A;  1KI6 A;  1E2M A;  1YH1 A;  4JBY A;  1OF1 A;  3M4N A;  2XTJ A;  1P73 A;  1E2L A;  3L04 A;  3M5D A;  1R4N B;  3M5C A;  1P7C A;  1QMG A;  1P72 A;  2FG6 C;  3KZC A;  4IVP A;  1KIM A;  1KI6 B;  1GKU B;  1P75 A;  3L05 A;  3KZO A;  1KI2 A;  1KI7 A;  1E2I A;  1E2J A;  1KI4 A;  2G7M C;  1R4M B;  1KI8 A;  1QHI A;  3FR7 A;  3FR8 A;  3F0T A;  4IVR A;  2VTK A; 
#chains in the KnotProt database with same CATH homology
 3KZN A;  1LNS A;  3FSG A;  3L02 A;  1JS1 X;  1DBI A;  3KZM A;  3KZK A;  3L06 A;  3M4J A;  1YH1 A;  3M4N A;  2XTJ A;  3L04 A;  3M5D A;  3M5C A;  2FG6 C;  3KZC A;  1GKU B;  3L05 A;  3KZO A;  2G7M C;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling